Skip to main content

Table 3 Correlation coefficients between experimental activity on 35 HMBS variants measured in [49] and the fitness values obtained by the assessed predictors and by experimental yeast complementation assays [44]. The best score for each metric is indicated in bold

From: FiTMuSiC: leveraging structural and (co)evolutionary data for protein fitness prediction

Method

Spearman

Pearson

Experimental

0.77

0.72

FiTMuSiC

0.53

0.85

FATHMM

0.53

0.57

PROVEAN

0.19

0.50

DEOGEN2

0.41

0.57

PolyPhen-2

0.38

0.53

EVE*

0.40

0.71

Sequence UNET

0.08

0.35

MutPred2

0.23

0.49

AlphaMissense

0.53

0.94

  1. *EVE’s predictions are available for 34/35 variants; the missing value was set to the median
Back to article page

Human Genomics

ISSN: 1479-7364