Fig. 1
From: FiTMuSiC: leveraging structural and (co)evolutionary data for protein fitness prediction
Contributions of structural and evolutionary features to HMBS fitness, represented by \(\mathcal {Z}_{\text {str}}\) and \(\mathcal {Z}_{\text {evo}}\), respectively. Negative z-scores (indicating mutations less fit than average mutations) are in red, close to zero scores in white and positive scores (indicating mutations fitter than average mutations) in blue. a, b Catalytic region, with the catalytic residues K98, D99, R149, R150, R167, R173 and C261 shown in sticks, and the substrate in green; c, d Salt bridge partners E250 and R116 shown in sticks; e, f Cluster of the three buried hydrophobic residues V124, I186 and L193 shown in sticks