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Fig. 1 | Human Genomics

Fig. 1

From: Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults

Fig. 1

Manhattan plots and conditional quantile-quantile (QQ) plots showed genetic vulnerabilities of cataract and hearing difficulties. (A) Manhattan plots displaying previous GWAS Results for cataract (GERA + UK Biobank) with the p values of all SNPs [16]. (B) Manhattan plots showing previous GWAS Results for hearing difficulties phenotypes (UK Biobank) [18]. The threshold for genome-wide significance (p < 5 × 10− 8) is indicated by a red dotted line. Loci that reached genome-wide significance in phenotypes are annotated with gene symbols. (C, D) QQ plots are shown of observed versus expected -log10 P values in the primary phenotype (e.g.cataracts) as a function of significance of association with a secondary phenotype (e.g., hearing difficulties). (E) The Venn diagram depicts the estimated number of trait-influencing variants shared (gray) between cataracts (left circle) and hearing difficulties phenotypes (right circle). The number of trait-influencing variants in thousands is shown, with the standard error in thousands provided. The size of the circles reflects the polygenicity of cataract or hearing difficulties, with larger circles corresponding to greater polygenicity and vice versa

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Human Genomics

ISSN: 1479-7364