Fig. 3

Results of TWAS and COLOC analyses.(A) A bar graph displaying the number of associations obtained using TWAS (GTEx and CONTENT) and COLOC, which passed the threshold for each analysis. The results are represented by different colors: green (type 2), orange (type 3), and blue (type 4). (B) Bar graphs showing the results of TWAS using individual tissue panels of GTEx. (C) Bar graphs displaying the results of TWAS using individual tissue panels of CONTENT. The bars are color-coded according to MPB types. Ternary plots showing TWAS and COLOC results for (D) MPB type 2, (E) type 3, and (F) type 4, respectively. PP0 + PP1 + PP2 indicates underpowered signals; PP3 indicates independent variants between phenotype and gene expression; and PP4 indicates colocalized variants where the causal SNP is associated with both phenotype and gene expression. Non-significant TWAS associations are represented with gray points, while significant associations are marked in blue, of which with a high posterior probability of colocalized signals are highlighted in red. Venn diagrams represent the number of associations from GTEx, CONTENT, and COLOC for (G) MPB type 2, (H) type 3, and (I) type 4, respectively. Genes used for further analysis are indicated in bold