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Fig. 2 | Human Genomics

Fig. 2

From: The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

Fig. 2

Schematic representation of MAPK1 and MAPK3 domain architecture. The N-terminal lobe contains the P-loop (pink) and the αC-helix (red); the C-terminal lobe contains the catalytic HRD (orange), the conserved DFG sequence (cyan) and the residues T185 and Y187 (MAPK1), and T202 and Y204 (MAPK3) important for the protein activation and catalysis. The N-terminal lobe and the C-terminal lobe are connected by a hinge (green). All the residues mutated in the variants object of this study are indicated

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Human Genomics

ISSN: 1479-7364