Table 1 RNA-seq datasets from studies on human neurological disorder, which yielded novel candidate genes with the T2T-CHM13 assembly
Disorder | Experimental design | Abbreviation | N (ctrl vs case) | Publication |
|---|---|---|---|---|
Alzheimer’s disease | Alzheimer’s patient’s induced neurons | AD/n | 8;10 | [9] |
Amyotrophic lateral sclerosis | Single-cell SOD1 E100G ALS iPSC-derived motor neurons | ALS/sc | 192;192 | [10] |
Amyotrophic lateral sclerosis | Patient iPSC-derived motor neurons harboring SOD1 mutations | ALS/mn | 3;2 | [11] |
Amyotrophic lateral sclerosis | CRISPR/Cas9-mediated targeted gene correction in patient iPSCs | ALS/crispr | 2;2 | [12] |
Autism spectrum disorder | NSCs derived from patient fibroblasts | ASD/nsc | 5;8 | [13] |
Autism spectrum disorder | Postmortem brains | ASD/pb | 2;2 | [14] |
Epilepsy | Dentate granule cells from hippocampi from patients with mesial temporal lobe epilepsy | E/dc | 14;8 | [15] |
Epilepsy | Patient primary skin fibroblasts | E/pf | 5;6 | [16] |
Epilepsy | Patient-derived neuronal cells | E/nc | 3;3 | [17] |
Epilepsy | Patient-derived neuronal astrocytes | E/na | 3;3 | [17] |
Epilepsy | Patient-derived neuronal oligodendroglial progenitor cells | E/nopc | 3;3 | [17] |
Glioblastoma | Endothelial cells isolated from post-mortem and resection surgery from human cortex | Gliob/ec | 7;5 | [18] |
Glioma | Patient-derived glioma | Glio | 6;16 | [19] |
m.3242 A > G mtDNA mutation | Pateient fibroblasts | mtDNA/m.3243 | 6;6 | [20] |
Multiple sclerosis | Patient CD4 + T cells | MS/CD4 | 5;5 | [21] |
Multiple sclerosis | Patient CD19 + B cells | MS/CD19 | 6;6 | [21] |
Multiple sclerosis | Patient white matter lesions | MS/bl | 25;72 | [22] |