Fig. 6
From: Epigenomic signature of major congenital heart defects in newborns with Down syndrome
Comparison of DS-CHD DMRs with DS versus TD samples. A Percent of DS-CHD DMRs and background regions that were significantly differentially methylated in DS versus TD samples. Z test for two population proportions, Sex Combined (z = 1.7343, two-tailed p = 0.08364), Females Only (z = 1.93, two-tailed p = 0.0536), Males Only (z = 1.8808, two-tailed p = 0.0601). +  = p < 0.1. B Percent of DS-CHD DMRs that were methylated in same direction in DS versus TD as in DS-CHD versus DS non-CHD. Z test for two populations proportions, Sex Combined (z =  − 0.4274, two-tailed p = 0.6672), Females Only (z =  − 0.8936, two-tailed p = 0.37346), Males Only (z = 6.5357, two-tailed p < 0.00001). **** = p < 0.00001. C Heatmap showing DS-CHD DMRs that were significant (q < 0.05) in DS versus TD samples mapped to genes. Red indicates hypermethylation in CHD compared to non-CHD, while blue represents hypomethylation, with stronger shades representing a greater percent methylation difference and gray meaning that that DMR was not significant for that comparison. Black dots indicate that methylation is in the same direction for DS versus TD as DS-CHD versus DS non-CHD, while white dots indicate methylation is in the opposite direction