Fig. 2
From: Whole-exome sequencing reveals candidate high-risk susceptibility genes for endometriosis
Histology and p53 status of high-grade serous carcinomas of individuals II-2 and II-3. A Dilated glands of endometriosis surrounded by endometrial type stroma (marked with arrows) and invasive glands of high-grade serous carcinoma (lower right quadrant, marked with a dashed line) in the ovary of individual II-2 (hematoxylin–eosin (HE) staining, original magnification × 4). B Serous carcinoma in the lumen of the fallopian tube of individual II-3 (HE staining, original magnification × 4). C Tumor epithelium with high-grade nuclear features and mitoses. Individual II-2 (HE staining, original magnification × 20). D Papillary structures of serous carcinoma with high-grade nuclear features and multiple mitoses. Individual II-3 (HE staining, original magnification × 20). E, F Strong p53 nuclear staining support the diagnosis of high-grade serous carcinoma of individuals II-2 and II-3, respectively (original magnification × 4)