Fig. 5
From: Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids
Proportions of the end positions of NFR and NBR fragments in repeat regions. A The proportion of fragment ends from the plasma sample in entire RepeatMasker-defined repeat regions. B–D The proportion of fragment ends from the plasma sample in RepeatMasker-defined repeat classes (B), subclasses of simple repeats (C), and subclasses of satellite repeats (D). E The proportion of fragment ends from organoid samples in entire RepeatMasker-defined repeat regions. F–H The proportion of fragment ends from organoid samples in RepeatMasker-defined repeat classes (F), subclasses of simple repeats (G), and subclasses of satellite repeats (H). Blue horizontal bars represent the proportions of RepeatMasker-defined repeats in the human genome. Black dots represent the value for each replicate. Red error bars represent the standard error of the mean. Statistical analyses were performed using the R package rstatix with Welch’s t test (ns: not significant; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001)