Fig. 4
From: Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids
End motifs of cfDNA fragments. End motifs were constructed using 5 million randomly selected NFR and NBR fragments. Breakpoints were defined as the points between the 3′ and 5′ ends and are indicated by gray dashed lines and triangle symbols. Representative results for GNO (A and B) and GCO (C and D) samples in the proliferative (A and C) and apoptotic (B and D) states are shown. Data were similar for other tissue types (Additional file 1: Fig. S5)