Fig. 2
From: Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids
Fragment size analysis of cfDNA. A Fragment size distribution of cfDNA in plasma based on the insert size. The black line represents nuclear DNA, and the red line represents mitochondrial DNA. The gray dashed lines and the numbers indicate peak sizes. B Fragment size distribution of cfDNA in proliferation and apoptosis organoid samples based on read lengths for fragments less than 150 bp and insert size otherwise. The gray dashed lines and the numbers indicate peak sizes. The light blue long dashed lines and the numbers indicate the cutoff point (118 bp) for separating groups based on fragment size. C, D The proportions of short (≤ 118 bp) and long (> 118 bp) fragments in plasma (C) and organoids (D)