Fig. 2
From: RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome
RUNX1 dependency across cancer cell lines from the Cancer Dependency Map portal (depma.org). The Chronos dependency score is based on data from a cell depletion assay. A lower score indicates a higher probability that the gene (RUNX1) is essential for a given cell line. A score of 0 indicates a gene is not essential, − 1 is comparable to the median of all pan-essential genes. Note that a significant proportion of Lymphoid and particularly Myeloid cancer cell lines—but not other cancer types- require RUNX1 expression for survival, as suggested by a Chronos dependency score below − 0.5. Importantly, RUNX1 dependency across Lymphoid and Myeloid cancer cell lines is significantly correlated to the level of RUNX1 mRNA expression in each cell line (not shown)