Fig. 1
From: RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome
A. Domain organization of the RUNX family of transcription factors. General domain architecture of the mammalian RUNX family members. B. RUNX1 exon organization and major alternative splicing isoforms. Major RUNX1 variants produced by alternative promoter/splicing mechanisms (see main text and BOX for details). C. RUNX-CBFβ form heterodimers to interact with DNA and regulate transcription. Heterodimerization of RUNX TFs with CBFβ is required for enhanced DNA binding, stability and interaction with other transcriptional regulators, leading to induction or repression of target genes