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Fig. 5 | Human Genomics

Fig. 5

From: Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein

Fig. 5

Age-related transcriptome profiling in abcb4 knockout zebrafish brain a Summary of significant DE genes from RNA-seq analysis of brain tissues between WT and abcb4 knockout zebrafish at 2 and 30 months. Gene Set Enrichment Analysis (GSEA) of age-associated DE genes (FDR < 0.5) in brain tissue of WT b and abcb4 mutant c (see Additional file 3 for detailed gene lists of GSEA). d Radial graph depicting the three enriched pathways more negatively regulated with age in abcb4-mutated brain than WT. e Heatmaps illustrate the relative level of transcripts in the enriched pathways from GSEA

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Human Genomics

ISSN: 1479-7364