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Fig. 4 | Human Genomics

Fig. 4

From: Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer

Fig. 4

Differential microbial abundance and their association with PML and OSCC. A Log-CPM normalized relative proportions of microbial profiles of Phylum, Genus and Species level stratified by histopathological grouping. B Associations of differentially abundant microbes with human genes and host-response pathways are outlined. The node size denotes the total number of associations for a microbe or a gene, and the edges' thickness is proportional to the enrichment score between a microbe and a gene. The node color indicates whether the gene was up- (red) or down-regulated (blue) in the corresponding host transcriptome differential analysis. The gene-pathway edges denote enrichment by over-representation analysis

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