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Fig. 5 | Human Genomics

Fig. 5

From: Transcriptome and proteome analysis reveals the anti-cancer properties of Hypnea musciformis marine macroalga extract in liver and intestinal cancer cells

Fig. 5

RT- and ChIP-qPCR analysis of downregulated target genes. A RT-qPCR analysis of selected downregulated genes in Ls174 and HepG2 cells following treatment with seaweed extracts. Y-axis shows fold change of expression in treated cell levels compared to control that corresponds to expression levels in untreated cells. Asterisks mark statistical significance of fold changes based on ANOVA. B ChIP-qPCR analysis of downregulated target genes following immunoprecipitation of p53 in treated and untreated HepG2 and Ls174 cells. Y-axis shows fold change compared to the chromatin of control loci; axis range matches the one of Fig. 4B for direct comparison. C Protein network interaction of the top 20 up-regulated and top 20 down-regulated genes in HepG2 cells D Protein network interaction of the top 20 up-regulated and top 20 down-regulated genes in Ls174 cells. Nodes correspond to proteins, edges indicate known (cyan:database curated, purple:experimentally determined) or predicted (green:gene neighborhood, red:gene fusions, blue:protein co-occurence, black:gene co-expression) protein–protein interactions

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Human Genomics

ISSN: 1479-7364