Table 1 Distribution (median, maximum, and minimum) of polygenicity parameters across phenotypic categories in populations of East Asian and European descent (EAS and EUR, respectively)

Body structures

4

7.1e−3

(1e−2–4.7e−3)

2e−5

(1e−4–1e−5)

2e−6

(3e−6–1e−6)

1

5e−3

 < 1e−6

2e−6

Cardiovascular

22

5e−3

(6.7e−3–6e−4)

7.4e−5

(8e−4– < 1e−6)

1e−6

(2e−5– − 2e−4)

18

5e−3

(5e−3–1.7e−3)

1e−4

(3e−4– < 1e−6)

2e−6

(1e−5– − 2e−5)

Dermatological

4

5e−3

(5.1e−3–5e−5)

 < 1e−6

(1.3e−2– < 1e−6)

5e−6

(1.1e−1– − 1e−4)

4

5e−3

(5e−3–4.4e−3)

3e−4

(4e−4– < 1e−6)

 − 2e−5

(− 2e−6– − 2e−4)

Ear, nose, throat

5

5e−3

(6.5e−3–5e−3)

2e−4

(6e−4– < 1e−6)

 − 1e−5

(1e−5– − 1e−4)

5

5e−3

(5e−3–4e−4)

1e−4

(2.1e−3–1e−4)

1e−6

(1e−5– − 1e−5)

Endocrine

5

5e−3

(5e−3–1e−4)

4e−5

(8.9e−3– < 1e−6)

1e−5

(2e−5– − 3e−6)

5

1e−4

(1.4e−3–5e−5)

8.1e−3

(1.8e−2–4e−4)

1e−5

(2e−5–4e−6)

Environment

1

5e−3

1e−4

 − 2e−6

1

5e−3

5e−5

1e−6

Gastrointestinal

8

5e−3

(5e−3–1.1e−3)

4e−5

(6e−4– < 1e−6)

1e−6

(3e−5– − 2e−5)

7

5e−3

(1.1e−2–1e−3)

3e−5

(8e−4– < 1e−6)

4e−6

(1e−5– − 3e−6)

Hematological

18

1.5e−3

(5e−3–2e−4)

1e−4

(3e−4– < 1e−6)

1e−6

(1e−5– − 1.3e−3)

4

5e−3

(5e−3–5e−3)

4e−5

(1e−4– < 1e−6)

1e−6

(3e−6– − 1e−4)

Immunological

28

5e−3

(7.1e−3–2e−5)

2e−4

(1e−2– < 1e−6)

 < 1e−6

(8e−5– − 2e−4)

27

5e−3

(6.7e−3–3e−5)

1e−4

(3.6e−2– < 1e−6)

2e−6

(2e−5– − 6e−4)

Medication

22

5e−3

(6.2e−3–1e−4)

1e−4

(3.2e−3–1e−5)

1e−6

(1e−5– − 3e−5)

0

NA

NA

NA

Metabolic

31

1.8e−3

(5.2e−3–2e−5)

1e−4

(7.9e−3– < 1e−6)

1e−6

(1e−5– − 4e−5)

15

5e−3

(0.78–3e−5)

1e−4

(4.3e−2– < 1e−6)

4e−6

(1e−4– − 2e−5)

Musculoskeletal

9

5e−3

(5e−3–1e−4)

 < 1e−6

(5e−3– < 1e−6)

1e−6

(5e−5– − 4e−4)

9

5e−3

(1.1e−2–1.7e−3)

5e−5

(4e−4– < 1e−6)

2e−6

(1e−5– − 4e−4)

Neoplasms

17

5e−3

(6e−3–3e−5)

3e−4

(3.2e−2– < 1e−6)

2e−6

(1e−4– − 1e−4)

17

5e−3

(5e−3–2e−5)

2e−4 (3e−2– < 1e−6)

4e−6

(3e−5– − 3e−5)

Neurological

7

5e−3

(5.2e−3–3.2e−3)

1e−4

(1.8e−3– < 1e−6)

 − 1e−5

(4e−6– − 2e−4)

6

5e−3

(5e−3–3.6e−3)

1e−4

(2e−4– < 1e−6)

 − 4e−6

(1e−5– − 4e−5)

Ophthalmological

8

5e−3

(5e−3–8e−4)

5e−5

(4e−4– < 1e−6)

 < 1e−6

(2e−5– − 2e−5)

7

2e−3

(5e−3–3e−5)

3e−4

(2e−2– < 1e−6)

5e−6

(1e−5– − 2e−6)

Psychiatric

5

5e−3

(6.7e−3–5e−3)

2e−4

(1.8e−3– < 1e−6)

 − 2e−5

(1e−5– − 2e−4)

5

5e−3

(9e−3–5e−3)

1e−4

(3e−4–1e−4)

2e−6

(3e−6– − 1e−5)

Respiratory

9

5e−3

(5e−3–5e−3)

 < 1e−6

(2e−4– < 1e−6)

 − 1e−5

(1e−5– − 1e−4)

9

5e−3

(8.4e−3–2e−4)

1e−4

(2.1e−3–2e−5)

 − 3e−6

(1e−5– − 1e−5)

Urogenital

12

5e−3

(5.5e−3–3e−4)

4e−6

(1.5e−3– < 1e−6)

 − 2e−6

(3e−5– − 1e−4)

12

5e−3

(5e−3–1e−4)

1e−4

(1.4e−3– < 1e−6)

3e−6

(4e−6– − 2e−6)