Fig. 5

Distribution of mutational interactions across lymph node status. A Mutational interactions among Lymph node-positive (NPlus) and lymph node-negative (N0) tumors are represented here. Green squares within the matrix indicate Co-occurrence, and the brown squares indicate mutual exclusivity across genes. The color scheme indicates the strength of the association, with darker colors indicating stronger co-occurrence or mutual exclusivity between the genes. B Mutations identified candidate genes across oncogenic pathways in lymph node plus tumors are represented here. The percentage of mutated genes and samples mutated in each pathway are also represented. Asterisk indicates Fisher’s test P values for samples with TP53 mutations in N0 and NPlus groups. C Tumor Mutation Burden across lymph node-negative and lymph node-positive tumors