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Table 3 Current smokers (reference) versus the cessation time categories

From: Smoking-related dysregulation of plasma circulating microRNAs: the Rotterdam study

miRNA

Cessation < 5 years (N = 83)

Cessation > 5 and < 15 years (N = 161)

Cessation > 15 years (N = 535)

Beta

SE

P-value

Beta

SE

P-value

Beta

SE

P-value

miR-326

0.239

0.0711

8.25 × 10–04

0.206

0.0555

2.23 × 10–04

0.132

0.0396

8.65 × 10–04

miR-6769b-3p

− 0.0903

0.0275

1.10 × 10–03

− 0.0906

0.0218

3.84 × 10–05

− 0.0635

0.0148

1.89 × 10–05

miR-10b-5p

− 0.118

0.0464

1.14 × 10–02

− 0.194

0.0428

7.34 × 10–06

− 0.148

0.026

1.65 × 10–08

miR-6845-5p

− 0.134

0.0552

1.55 × 10–02

− 0.131

0.0425

2.24 × 10–03

− 0.139

0.0302

4.70 × 10–06

miR-30a-3p

− 0.14

0.0585

1.73 × 10–02

− 0.0845

0.0435

5.23 × 10–02

− 0.131

0.0322

5.17 × 10–05

miR-6738-5p

− 0.134

0.057

1.95 × 10–02

− 0.126

0.0422

2.92 × 10–03

− 0.144

0.0357

6.16 × 10–05

miR-30a-5p

− 0.0632

0.0283

2.57 × 10–02

− 0.101

0.0226

1.03 × 10–05

− 0.0855

0.0161

1.44 × 10–07

miR-10a-5p

− 0.101

0.0472

3.21 × 10–02

− 0.161

0.0389

3.99 × 10–05

− 0.125

0.0278

7.22 × 10–06

miR-4505

− 0.0608

0.0296

4.03 × 10–02

− 0.0812

0.0237

6.54 × 10–04

− 0.0425

0.0168

1.13 × 10–02

miR-6821-5p

− 0.125

0.0647

5.49 × 10–02

− 0.182

0.0505

3.44 × 10–04

− 0.174

0.0359

1.39 × 10–06

miR-27a-3p

− 0.105

0.0571

6.63 × 10–02

− 0.157

0.0454

5.84 × 10–04

− 0.173

0.0323

1.13 × 10–07

miR-126-5p

− 0.105

0.0616

8.98 × 10–02

− 0.17

0.0495

6.44 × 10–04

− 0.134

0.0359

1.93 × 10–04

miR-149-3p

− 0.0893

0.0527

9.06 × 10–02

− 0.122

0.0417

3.73 × 10–03

− 0.148

0.0297

7.24 × 10–07

miR-29b-3p

− 0.0561

0.0352

1.12 × 10–01

− 0.158

0.0304

3.02 × 10–07

− 0.125

0.0205

1.41 × 10–09

miR-23a-3p

− 0.0849

0.0547

1.21 × 10–01

− 0.0807

0.0436

6.50 × 10–02

− 0.136

0.031

1.29 × 10–05

miR-195-5p

− 0.0673

0.0455

1.40 × 10–01

− 0.0932

0.0356

9.18 × 10–03

− 0.0956

0.0258

2.22 × 10–04

miR-1285-5p

0.108

0.0754

1.53 × 10–01

0.0646

0.0614

2.94 × 10–01

0.207

0.0426

1.37 × 10–06

miR-1237-5p

− 0.091

0.0641

1.56 × 10–01

− 0.126

0.05

1.18 × 10–02

− 0.185

0.0341

7.15 × 10–08

miR-1915-3p

0.0943

0.0685

1.69 × 10–01

− 0.179

0.053

7.97 × 10–04

− 0.206

0.0366

2.49 × 10–08

miR-6869-5p

0.0712

0.0519

1.71 × 10–01

− 0.0806

0.0403

4.61 × 10–02

− 0.134

0.0294

6.06 × 10–06

miR-8069

0.0768

0.0614

2.11 × 10–01

− 0.116

0.0481

1.59 × 10–02

− 0.126

0.0313

6.25 × 10–05

miR-6085

0.0996

0.0796

2.12 × 10–01

− 0.226

0.0616

2.72 × 10–04

− 0.212

0.0425

7.59 × 10–07

miR-93-5p

0.0629

0.0517

2.24 × 10–01

0.105

0.0401

9.25 × 10–03

0.0949

0.0293

1.25 × 10–03

miR-654-5p

0.0786

0.0658

2.32 × 10–01

− 0.14

0.0441

1.55 × 10–03

− 0.135

0.0324

3.39 × 10–05

miR-27b-3p

0.0486

0.041

2.36 × 10–01

− 0.159

0.0343

4.76 × 10–06

− 0.157

0.0233

3.00 × 10–11

miR-1913

0.0425

0.0359

2.37 × 10–01

0.0776

0.0276

5.20 × 10–03

0.059

0.0202

3.57 × 10–03

miR-126-3p

− 0.0543

0.0466

2.45 × 10–01

− 0.124

0.0367

7.85 × 10–04

− 0.107

0.0259

4.02 × 10–05

miR-1914-5p

0.0605

0.0534

2.57 × 10–01

0.0766

0.0406

5.96 × 10–02

0.0985

0.0288

6.47 × 10–04

miR-23b-3p

− 0.0538

0.0478

2.61 × 10–01

− 0.128

0.0385

9.11 × 10–04

− 0.154

0.0259

3.83 × 10–09

miR-150-5p

− 0.0796

0.0709

2.62 × 10–01

− 0.231

0.0543

2.48 × 10–05

− 0.203

0.0365

3.60 × 10–08

miR-100-5p

− 0.0541

0.0511

2.90 × 10–01

− 0.178

0.0416

2.09 × 10–05

− 0.135

0.0286

3.02 × 10–06

miR-29a-3p

− 0.0372

0.0392

3.44 × 10–01

− 0.134

0.0317

2.82 × 10–05

− 0.116

0.0207

3.37 × 10–08

let-7e-5p

0.0332

0.0464

4.74 × 10–01

− 0.0874

0.0383

2.28 × 10–02

− 0.125

0.0275

6.26 × 10–06

miR-146b-5p

− 0.015

0.0314

6.34 × 10–01

− 0.0503

0.0252

4.67 × 10–02

− 0.0741

0.018

4.14 × 10–05

miR-342-3p

− 0.0174

0.0388

6.55 × 10–01

− 0.102

0.0314

1.24 × 10–03

− 0.125

0.0249

5.89 × 10–07

miR-30b-5p

0.0134

0.0369

7.16 × 10–01

− 0.0796

0.0306

9.68 × 10–03

− 0.0723

0.0212

6.81 × 10–04

miR-92a-3p

0.0156

0.0457

7.34 × 10–01

0.0809

0.0361

2.53 × 10–02

0.0917

0.0266

5.93 × 10–04

let-7c-5p

0.00796

0.0302

7.92 × 10–01

− 0.0885

0.0265

8.98 × 10–04

− 0.0663

0.0177

1.87 × 10–04

miR-4632-5p

− 0.00905

0.0820

9.12 × 10–01

− 0.125

0.0641

5.18 × 10–02

− 0.18

0.0457

8.56 × 10–05

miR-155-5p

− 0.00327

0.0596

9.56 × 10–01

− 0.15

0.0488

2.20 × 10–03

− 0.121

0.035

5.77 × 10–04

miR-486-5p

0.00327

0.0638

9.59 × 10–01

0.16

0.0495

1.32 × 10–03

0.154

0.0366

2.79 × 10–05

  1. The table shows for the smoking-miRNAs the results from the linear regression analysis where tobacco smoking was the main exposure with current smokers as the reference group versus the different smoking cessation categories, and plasma miRNA levels as the main outcome. The Bonferroni-corrected threshold was set at P < 0.05/41 = 1.22 × 10–3. The p-values presented in bold passed the Bonferroni-corrected threshold. SE: standard error
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Human Genomics

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