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Table 4 SARS-CoV-2 variants and ACE2 SNPs and ACE1 rs1799752 (I/D) haplotypes

From: The impact of ACE2 polymorphisms (rs1978124, rs2285666, and rs2074192) and ACE1 rs1799752 in the mortality rate of COVID-19 in different SARS-CoV-2 variants

Haplotypes

Frequency

Alpha

Delta

Omicron

OR (95% CI)

OR (95% CI)

OR (95% CI)

CDCT

0.2205

1.00

2.62 (1.74–3.96)

1.16 (0.77–1.75)

TDCT

0.15

1.41 (1.11–1.79)

5.36 (3.67–7.83)

1.34 (0.92–1.96)

CDCC

0.1042

–

2.63 (1.80–3.85)

1.18 (0.80–1.73)

TITT

0.074

–

2.34 (1.56–3.51)

–

TDCC

0.0697

–

4.02 (2.55–6.33)

1.73 (1.11–2.71)

CICT

0.0552

3.83 (2.45–6.00)

1.80 (1.12–2.92)

–

TITC

0.0419

–

2.36 (1.46–3.81)

–

TICT

0.0346

3.54 (2.07–6.06)

5.69 (2.32–13.94)

–

CICC

0.0247

3.08 (1.78–5.35)

–

–

TICC

0.0163

8.85 (3.55–22.07)

3.70 (1.28–10.66)

–

  1. SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; ACE2, angiotensin-converting enzyme 2; SNPs, single nucleotide polymorphisms; OR, odds ratios; CI, confidence intervals