Table 2 ACE2 SNPs and ACE1 rs1799752 (I/D) polymorphism association with COVID-19 mortality adjusted by SARS-CoV-2 variants

Allele

C

3182 (69.0%)

2123 (52.0%)

–

–

–

–

T

1432 (31.0%)

1923 (48.0%)

–

–

–

–

Codominant

C/C

1355 (58.7%)

855 (42.3%)

1.00

< 0.0001*

5542.5

5580.8

C/T

472 (20.5%)

413 (20.4%)

1.60 (1.31–1.94)

T/T

480 (20.8%)

755 (37.3%)

2.43 (2.09–2.83)

Dominant

C/C

1355 (58.7%)

855 (42.3%)

1.00

< 0.0001*

5558.0

5589.8

C/T–T/T

952 (41.3%)

1168 (57.7%)

2.15 (1.87–2.47)

Recessive

C/C–C/T

1827 (79.2%)

1268 (62.7%)

1.00

< 0.0001*

5562.3

5594.1

T/T

480 (20.8%)

755 (37.3%)

2.14 (1.86–2.46)

Overdominant

C/C–T/T

1835 (79.5%)

1610 (79.6%)

1.00

0.64

5677.1

5709.0

C/T

472 (20.5%)

413 (20.4%)

1.04 (0.87–1.25)

Minor allele frequency (T)

0.31

0.48

–

–

–

–

ACE2 rs1978124

Allele

T

3070 (67.0%)

2786 (69.0%)

–

–

–

–

C

1544 (33.0%)

1260 (31.0%)

–

–

–

–

Codominant

T/T

1333 (57.8%)

1206 (59.6%)

1.00

< 0.0001*

5639.2

5677.4

T/C

404 (17.5%)

374 (18.5%)

1.72 (1.41–2.10)

C/C

570 (24.7%)

443 (21.9%)

0.85 (0.73–0.99)

Dominant

T/T

1333 (57.8%)

1206 (59.6%)

1.00

0.26

5676.0

5707.9

T/C–C/C

974 (42.2%)

817 (40.4%)

1.08 (0.95–1.23)

Recessive

T/T–T/C

1737 (75.3%)

1580 (78.1%)

1.00

< 0.0001*

5666.1

5697.9

C/C

570 (24.7%)

443 (21.9%)

0.78 (0.67–0.90)

Overdominant

T/T–C/C

1903 (82.5%)

1649 (81.5%)

1.00

< 0.0001*

5641.3

5673.2

T/C

404 (17.5%)

374 (18.5%)

1.80 (1.49–2.19)

Minor allele frequency (C)

0.33

0.31

–

–

–

–

ACE2 rs2285666

Allele

C

2647 (57.0%)

3200 (79.0%)

–

–

–

–

T

1967 (43.0%)

846 (21.0%)

–

–

–

–

Codominant

C/C

856 (37.1%)

1395 (69.0%)

1.00

< 0.0001*

5306.8

5345.0

C/T

935 (40.5%)

410 (20.3%)

0.33 (0.28–0.38)

T/T

516 (22.4%)

218 (10.8%)

0.23 (0.19–0.28)

Dominant

C/C

856 (37.1%)

1395 (69.0%)

1.00

< 0.0001*

5315.5

5347.3

C/T–T/T

1451 (62.9%)

628 (31.0%)

0.29 (0.25–0.33)

Recessive

C/C–C/T

1791 (77.6%)

1805 (89.2%)

1.00

< 0.0001*

5666.1

5697.9

T/T

516 (22.4%)

218 (10.8%)

0.33 (0.28–0.40)

Overdominant

C/C–T/T

1372 (59.5%)

1613 (79.7%)

1.00

< 0.0001*

5662.7

5594.6

C/T

935 (40.5%)

410 (20.3%)

0.46 (0.40–0.53)

Minor allele frequency (T)

0.43

0.21

–

–

–

–

ACE1 rs1799752 (I/D)

Allele

D

2181 (47.0%)

2583 (64.0%)

–

–

–

–

I

2433 (53.0%)

1463 (36.0%)

–

–

–

–

Codominant

D/D

526 (22.8%)

860 (42.5%)

1.00

< 0.0001*

5481.3

5519.5

I/D

1129 (48.9%)

863 (42.7%)

0.51 (0.44–0.59)

I/I

652 (28.3%)

300 (14.8%)

0.29 (0.24–0.35)

Dominant

D/D

526 (22.8%)

860 (42.5%)

1.00

< 0.0001*

5523.8

5555.7

I/D–I/I

1781 (77.2%)

1163 (57.5%)

0.43 (0.37–0.49)

Recessive

D/D–I/D

1655 (71.7%)

1723 (85.5%)

1.00

< 0.0001*

5562.8

5594.6

I/I

652 (28.3%)

300 (14.8%)

0.43 (0.37–0.50)

Overdominant

D/D–I/I

1178 (51.1%)

1160 (57.3%)

1.00

0.0057*

5669.7

5701.5

I/D

1129 (48.9%)

863 (42.7%)

0.84 (0.74–0.95)

Minor allele frequency (I)

0.53

0.36

–

–

–

–