Table 1 The frequencies of ACE2 and ACE1 polymorphisms between SARS-CoV-2 variants
Variables | SARS-CoV-2 variants | P value | ||
|---|---|---|---|---|
Alpha (n = 1395) | Delta (n = 1425) | Omicron BA.5 (n = 1510) | ||
Deceased/recovered patients | 632/763 (45.3/54.7%) | 913/512 (64.1/35.9%) | 478/1032 (31.7/68.3%) | < 0.001* |
Mean age ± SD | 54.7 ± 12.5 | 57.3 ± 12.1 | 52.4 ± 13.1 | < 0.001* |
Gender (male/female) | 735/660 (52.7/47.3%) | 760/665 (53.3/46.7%) | 765/745 (50.7/49.3%) | 0.317 |
ACE2 rs2074192 |  |  |  | < 0.001* |
CC | 744 (53.3%) | 637 (44.7%) | 829 (54.9%) | Â |
CT | 290 (20.8%) | 288 (20.2%) | 307 (20.3%) | Â |
TT | 361 (25.9%) | 500 (35.1%) | 374 (24.8%) | Â |
ACE2 rs1978124 |  |  |  | < 0.001* |
TT | 865 (62.0%) | 918 (64.4%) | 756 (50.1%) | Â |
TC | 196 (14.1%) | 136 (9.6%) | 446 (29.5%) | Â |
CC | 334 (23.9%) | 371 (26.0%) | 308 (20.4%) | Â |
ACE2 rs2285666 |  |  |  | < 0.001* |
CC | 831 (59.6%) | 850 (59.6%) | 570 (37.7%) | Â |
CT | 323 (23.2%) | 275 (19.6%) | 747 (49.5%) | Â |
TT | 241 (17.2%) | 300 (21.1%) | 193 (12.8%) | Â |
ACE1 rs1799752 (I/D) |  |  |  | < 0.001* |
DD | 474 (34.0%) | 539 (37.8%) | 373 (24.7%) | Â |
ID | 627 (44.9%) | 587 (41.2%) | 778 (51.5%) | Â |
II | 294 (21.1%) | 299 (21.0%) | 359 (23.8%) | Â |