Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity

Table 3 Binary logistic regression model for the aggressiveness in COVID-19 disease assessed by age and gender

Variable	Gene	Expression level	Asymptomatic/mild disease; N	Severe/critical disease; N	p-value	OR (CI 95%)
< 55 years old	ERG	Low	58	10	0.042	Ref.
	ERG	High	48	20		2.471 (1.033–5.654)
	ETV5	Low	60	18	0.606	Ref.
	ETV5	High	69	17		0.821 (0.389–1.735)
	AR	Low	56	12	0.473	Ref.
	AR	High	66	19		1.343 (0.600–3.007)
	MX1	Low	56	17	0.276	Ref.
	MX1	High	67	13		0.639 (0.286–1.429)
	ACE2	Low	55	13	0.973	Ref.
	ACE2	High	50	12		1.015 (0.424–2.431)
	TMPRSS2	Low	21	5	0.512	Ref.
	TMPRSS2	High	19	7		1.547 (0.420–5.704)
≥ 55 years old	ERG	Low	9	16	0.983	Ref.
	ERG	High	10	18		1.012 (0.329–3.117)
	ETV5	Low	10	22	0.625	Ref.
	ETV5	High	9	15		0.758 (0.249–2.309)
	AR	Low	8	28	0.016	Ref.
	AR	High	11	9		0.234 (0.072–0.761)
	MX1	Low	12	20	0.907	Ref.
	MX1	High	9	16		1.067 (0.360–3.159)
	ACE2	Low	10	11	0.560	Ref.
	ACE2	High	11	17		1.405 (0.448–4.410)
	TMPRSS2	Low	3	2	0.872	Ref.
	TMPRSS2	High	5	4		1.200 (0.130–11.052)
Male	ERG	Low	26	4	0.131	Ref.
	ERG	High	27	11		2.648 (0.748–9.380)
	ETV5	Low	23	7	0.795	Ref.
	ETV5	High	38	10		0.865 (0.289–2.587)
	AR	Low	31	7	0.414	Ref.
	AR	High	25	9		1.594 (0.520–4.884)
	MX1	Low	34	7	0.698	Ref.
	MX1	High	27	7		1.259 (0.394–4.029)
	ACE2	Low	35	6	0.156	Ref.
	ACE2	High	8	4		2.917 (0.664–12.813)
	TMPRSS2	Low	7	2	0.796	Ref.
	TMPRSS2	High	8	3		1.312 (0.168–10.264)
Female	ERG	Low	41	22	0.167	Ref.
	ERG	High	27	11		1.677 (0.805–3.494)
	ETV5	Low	46	33	0.448	Ref.
	ETV5	High	40	22		0.767 (0.386–1.552)
	AR	Low	32	33	0.005	Ref.
	AR	High	52	19		0.354 (0.173–0.725)
	MX1	Low	33	30	0.140	Ref.
	MX1	High	49	22		0.471 (0.173–1.280)
	ACE2	Low	29	18	0.477	Ref.
	ACE2	High	53	25		0.760 (0.357–1.619)
	TMPRSS2	Low	17	5	0.427	Ref.
	TMPRSS2	High	16	8		1.700 (0.549–6.297)

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