Table 2 Logistic regression analysis of risk of COVID-19 disease
From: Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity
Asymptomatic/mild disease N (%) | Severe/critical disease N (%) | OR (CI 95%) | p-value* | |
|---|---|---|---|---|
MX1 | 0.575 | |||
Male | ||||
Codominant | ||||
AA | 23 (20.1%) | 21 (29.6%) | 0.491 | |
AG | 47 (55.3%) | 33 (46.5%) | ||
GG | 15 (17.6%) | 17 (23.9) | ||
Dominant | ||||
AA | 23 (20.1%) | 21 (29.6%) | Ref. | 0.728 |
AG + GG | 62 (72.9%) | 50 (70.4%) | 0.883 (0.43–1.77) | |
Recessive | ||||
GG | 15 (17.6%) | 17 (23.9%) | Ref. | 0.332 |
AA + AG | 70 (82.4%) | 54 (76.1%) | 0.68 (0.32–1.49) | |
Female | ||||
Codominant | ||||
AA | 26 (37.7%) | 26 (18.4%) | 0.269 | |
AG | 52 (53.1%) | 33(47.8%) | ||
GG | 20 (20.4%) | 10 (14.5%) | ||
Dominant | ||||
AA | 26 (26.5%) | 26 (37.7%) | Ref. | 0.125 |
AG + GG | 72 (73.5%) | 43 (62.3%) | 0.59 (0.31–1.15) | |
Recessive | ||||
GG | 20 (20.4%) | 10 (14.5%) | Ref. | 0.327 |
AA + AG | 78 (79.6%) | 59 (85.5%) | 1.51 (0.66–3.47) | |
ACE2 | 0.855 | |||
Male** | ||||
C allele | 69 (81.2%) | 56 (78.9%) | Ref. | 0.720 |
T allele | 16 (18.8%) | 15 (21.1%) | 1.15 (0.53–2.54) | |
Female | ||||
Codominant | ||||
CC | 65 (66.3%) | 45 (65.2%) | 0.667 | |
CT | 32 (32.7%) | 22 (31.9%) | ||
TT | 1 (1%) | 2 (2.9%) | ||
Dominant | ||||
TT | 1 (1%) | 2 (2.9%) | Ref. | 0.368 |
CT + CC | 97 (99%) | 67 (97.1%) | 0.34 (0.03–3.88) | |
Recessive | ||||
CC | 65 (66.3%) | 45 (65.2%) | Ref. | 0.882 |
CT + TT | 33 (33.7%) | 24 (34.8%) | 1.05 (0.55–2.01) | |
TMPRSS2 | 0.460 | |||
Male | ||||
Codominant | ||||
AA | 28 (33.3%) | 25 (35.2%) | 0.967 | |
AG | 41 (48.5%) | 34 (47.9%) | ||
GG | 15 (17.9%) | 12 (16.9%) | ||
Dominant | ||||
AA | 28 (33.3%) | 25 (35.2%) | Ref. | 0.806 |
AG + GG | 56 (66.7%) | 46 (64.8%) | 0.92 (0.47–1.79) | |
Recessive | ||||
GG | 15 (17.9%) | 12 (16.9%) | Ref. | 0.876 |
AA + AG | 69 (82.1%) | 59 (83.1%) | 1.07 (0.46–2.46) | |
Female | ||||
Codominant | ||||
AA | 41 (41.8%) | 16 (23.2%) | 0.036 | |
AG | 39 (39.8%) | 39 (56.5%) | ||
GG | 18 (18.8%) | 14 (20.3%) | ||
Dominant | ||||
AA | 41 (41.8%) | 16 (23.2%) | Ref. | 0.012 |
AG + GG | 57 (58.2%) | 53 (76.8%) | 2.38 (1.20–4.74) | |
Recessive | ||||
GG | 18 (18.4%) | 14 (20.3%) | Ref. | 0.756 |
AA + AG | 80 (81.6%) | 55 (79.7%) | 0.88 (0.41–1.93) | |