Table 2 ACE2 variants stability profile and energy calculations
ACE2 mutant | SNP | AA substitution | Stability | RI (0–10) | ΔΔG (Kcal/mol) |
|---|---|---|---|---|---|
c.2402T>G | rs1464340051 | V801G | Decrease | 9 | − 3.20 |
c.2353G>A | rs373153165 | D785N | Decrease | 8 | − 2.16 |
c.2302C>T | rs140016715 | R768W | Decrease | 6 | − 1.01 |
c.2258T>C | rs931448406 | I753T | Decrease | 4 | − 1.24 |
c.2191C>T | rs147311723 | L731F | Decrease | 6 | − 0.35 |
c.2191C>A | NA | L731I | Decrease | 5 | − 0.55 |
c.2179A>G | NA | I727V | Decrease | 6 | − 0.66 |
c.2158A>G | rs41303171 | N720D | Decrease | 7 | − 1.38 |
c.2129G>A | rs370187012 | R710H | Decrease | 8 | − 1.85 |
c.2122C>T | rs776995986 | R708W | Decrease | 7 | − 1.21 |
c.2074T>C | rs149039346 | S692P | Increase | 1 | 1.41 |
c.2002G>A | rs200180615 | E668K | Decrease | 8 | − 1.10 |
c.1972G>A | rs1295899858 | V658I | Decrease | 5 | − 0.37 |
c.1913A>G | rs183135788 | N638S | Decrease | 8 | − 1.11 |
c.1880C>T | rs748163894 | A627V | Decrease | 5 | − 0.86 |
c.1774T>C | NA | F592L | Decrease | 8 | − 2.97 |
c.1724G>T | NA | G575V | Decrease | 3 | − 0.13 |
c.1501G>A | rs140473595 | A501T | Decrease | 5 | − 0.96 |
c.1402A>G | rs191860450 | I468V | Decrease | 8 | − 0.70 |
c.1149G>A | NA | M383I | Decrease | 2 | − 0.02 |
c.517G>A | rs754511501 | G173S | Decrease | 7 | − 0.48 |
c.476A>G | rs746034076 | N159S | Decrease | 6 | − 0.47 |
c.446A>G | rs373252182 | N149S | Decrease | 4 | − 0.40 |
c.114C>G | NA | D38E | Increase | 3 | 0.02 |
c.97A>G | NA | N33D | Decrease | 4 | − 2.10 |
c.77A>G | rs4646116 | K26R | Decrease | 5 | − 0.34 |
c.62T>C | rs1244687367 | I21T | Decrease | 8 | − 2.16 |
c.55T>C | rs73635825 | S19P | Increase | 6 | 0.39 |