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Table 10 Results for GPC5, rs9523787. Corrected P values using the Benjimini-Hochberg (PBH) and Bonferroni (PBon) methods are presented below the uncorrected P value. Significance measures are suggestive only as cell counts fell below the minimum required to perform chi-square analysis in the disease subgroups (n < 5)

From: An investigation of genetic polymorphisms in heparan sulfate proteoglycan core proteins and key modification enzymes in an Australian Caucasian multiple sclerosis population

 

GPC5

rs9523787

Polymorphism

Genotypes

 

Alleles

Group

GG (%)

GT (%)

TT (%)

P

(PBH, PBon)

HWE

G (%)

T (%)

P

OR (95% CI)

MS total cases (n= 205)

146 (71.2)

54 (26.3)

5 (2.5)

0.609

(0.812, 1)

0.998

346 (84.4)

64 (15.6)

0.464

0.87

PP case (n= 54)

37 (68.5)

17 (31.5)

0 (0)

0.558

 

91 (84.3)

17 (15.7)

0.660

0.88

SP case (n= 57)

40 (78.4)

9 (17.7)

2 (3.9)

0.153

 

89 (87.3)

13 (12.7)

0.246

0.69

RR case (n= 94)

69 (69.0)

28 (28.0)

3 (3.0)

0.811

 

166 (83.0)

34 (17.0)

0.868

0.96

Control (n= 188)

126 (67.0)

58 (30.9)

4 (2.1)

 

0.366

310 (82.4)

66 (17.6)

  

HapMap CEU (%)

64.6

27.4

8

  

78.3

21.7

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