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Table 1 Summary of LRF/ZBTB7A functions in cancer. The protein is notorious for exerting tissue- and context-dependent oncogenic or oncosuppressive functions, through multiple molecular interactions

From: The multi-faceted functioning portrait of LRF/ZBTB7A

Cancer

Function

Molecular partners

Biological process

Reference

Lymphoma

Oncogenic

BCL6‚ p19Arf

Cell transformation, cell growth

38

Acute myeloid leukemia

Oncogenic

RUNX1/RUNX1T1

Proliferation

39

Lung cancer

Oncogenic

miR-125a, miR-520e

Cell cycle, cell growth, proliferation, apoptosis, invasion

40-43, 69, 85

Oncosuppressive

HP1γ, AXL, PVT1, ELK1

Proliferation, migration

88

Hepatocellular carcinoma

Oncogenic

miR-125, miR-137, MEF2D, p53, p21,p27, cyclins, CDKs, PI3K/AKT, RAS/RAF/MEK/ERK, BCL2, FAS receptor, FADD, caspase-8, caspase-10

Cell cycle, proliferation, apoptosis, migration/metastasis, invasion

37, 44-48, 65, 66

Oncosuppressive

miR-106b

Proliferation, apoptosis

83

Prostate cancer

Oncogenic

STRN4, EGF

Proliferation, apoptosis

49, 50, 79

Oncosuppressive

Sox9, AR

Senescence, proliferation, invasion

89, 92

Ovarian cancer

Oncogenic

MT1-MMP

Migration/metastasis, invasion

51

Breast cancer

Oncogenic

Survivin, SP1,Smad4

Proliferation, apoptosis

52-55, 77

Gastric cancer

Oncogenic

C/EBPα/ miR-100

Proliferation, migration/metastasis

55

Oncosuppressive

Not defined

Cell cycle, apoptosis, migration/metastasis

95

Glioma

Oncogenic

AKT, cyclins, CDKs, NF-κB, Survivin

Cell cycle, proliferation, apoptosis, migration/metastasis

56

Sarcoma/mesenchymal tumors

Oncogenic

p21, p53, miR-663a, LncRNA GAS5, circular RNA of LRF/ZBTB7A - ILF2/3

Cell cycle, proliferation, apoptosis, migration/metastasis, invasion, angiogenesis

57, 58, 68, 103

Oncosuppressive

DLK1, Sox9

Cell transformation, proliferation

93, 103

Colorectal cancer

Oncogenic

DAP5/p53, ETS-1

Cell cycle, proliferation, apoptosis, migration/metastasis, invasion

59-62

Renal carcinoma

Oncogenic

miR-137

Proliferation, invasion

63

Liver cancer

Oncogenic

miR-21, Sprouty1

Cell growth, proliferation

84

Bladder cancer

Oncogenic

TGF-β

Cell growth, migration/metastasis, invasion

81

Melanoma

Oncosuppressive

MCAM

Migration/metastasis

96