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Fig. 5 | Human Genomics

Fig. 5

From: Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms

Fig. 5

Tobacco-smoking associated genes map to interconnected interferon and stress response signaling networks. Ingenuity Pathway Analysis network diagram connecting Sash1 with selected interferon signaling molecules and stress response transcription factors. Sash1 encodes a scaffolding protein in the toll-like receptor (TLR4) pathway and is upregulated in tobacco smokers in the present and previous studies [14,15,16,17,18, 20]. The Krüppel-like transcription factor Klf4 associated with smoking in other cell types [50, 51] was also included. Nodes highlighted in red were upregulated in models contrasting HIV+ smokers vs. HIV− non-smokers (FDR-adjusted p value < 0.15, absolute log2 FC > 0.25); edges denote previously described positive or negative regulatory interaction and associations

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Human Genomics

ISSN: 1479-7364