Patients | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotypes | Age (years) | BMI (kg/m2) | Previous implantation failure (n) | PT (s) | aPTT (s) | PLT (103/μl) | Homocysteine (μmol/L) | Folate (mg/ml) | Total cholesterol (mg/dl) | Uric acid (mg/dl) | BUN (mg/dl) | Creatinine (mg/dl) |
Mean ± SD (118) | Mean ± SD (117) | Mean ± SD (112) | Mean ± SD (110) | Mean ± SD (110) | Mean ± SD (113) | Mean ± SD (35) | Mean ± SD (46) | Mean ± SD (47) | Mean ± SD (58) | Mean ± SD (108) | Mean ± SD (108) | |
miR-25 T>C | ||||||||||||
 TT | 34.0 ± 3.27 | 21.0 ± 2.96 | 1.1 ± 1.55 | 11.1 ± 1.64 | 29.3 ± 3.53 | 230.7 ± 53.46 | 6.6 ± 1.41 | 16.1 ± 12.50 | 192.2 ± 48.12 | 3.9 ± 1.02 | 10.1 ± 2.95 | 0.8 ± 0.09 |
 TC | 34.5 ± 3.04 | 21.3 ± 1.78 | 0.9 ± 1.18 | 11.3 ± 0.55 | 28.6 ± 2.93 | 243.3 ± 75.15 | 6.4 ± 0.91 | 13.9 ± 4.13 | 177.5 ± 23.97 | 4.0 ± 0.74 | 11.2 ± 2.16 | 0.8 ± 0.12 |
 CC | 36.0 | 20.5 | 2.0 | 11.6 | 31.4 | 319.0 | 4.9 | 12.8 | 157.0 | 3.3 | 10.3 | 0.8 |
 P value | 0.716 | 0.842 | 0.700 | 0.829 | 0.546 | 0.268 | 0.436 | 0.889 | 0.322 | 0.735 | 0.289 | 0.319 |
miR-32C>A | ||||||||||||
 CC | 34.2 ± 3.14 | 20.9 ± 2.69 | 1.2 ± 1.48 | 11.2 ± 1.24 | 29.4 ± 3.58 | 228.5 ± 57.00 | 6.5 ± 1.30 | 16.9 ± 11.66 | 188.3 ± 45.71 | 3.9 ± 0.99 | 10.2 ± 2.80 | 0.8 ± 0.10 |
 CA | 33.8 ± 3.61 | 21.3 ± 3.02 | 0.9 ± 1.49 | 10.6 ± 2.32 | 28.5 ± 2.50 | 251.4 ± 58.53 | 6.8 ± 1.65 | 9.3 ± 6.84 | 192.7 ± 43.39 | 3.8 ± 0.83 | 11.4 ± 2.81 | 0.8 ± 0.09 |
 AA | 35.0 ± 2.83 | 22.8 ± 4.45 | 0.000 | 10.5 ± 0.50 | 26.9 ± 2.97 | 317.0 ± 59.40 | N/A | N/A | 186.5 ± 4.95 | 0.000 | 8.0 ± 1.41 | 0.8 ± 0.07 |
 P value | 0.789 | 0.571 | 0.412 | 0.167 | 0.364 | 0.037 | 0.600 | 0.133 | 0.927 | 0.562 | 0.111 | 0.600 |
miR-125aC>T | ||||||||||||
 CC | 34.4 ± 3.00 | 21.1 ± 2.69 | 1.0 ± 1.42 | 11.0 ± 1.60 | 28.9 ± 3.24 | 235.8 ± 55.54 | 6.5 ± 1.08 | 17.2 ± 12.31 | 188.7 ± 42.73 | 3.9 ± 0.94 | 10.2 ± 2.61 | 0.8 ± 0.09 |
 CT | 33.0 ± 3.94 | 20.7 ± 3.12 | 1.7 ± 1.69 | 11.4 ± 0.53 | 30.7 ± 3.97 | 223.8 ± 73.14 | 6.6 ± 2.10 | 10.3 ± 3.87 | 191.5 ± 56.72 | 4.2 ± 1.04 | 10.9 ± 3.81 | 0.8 ± 0.12 |
 TT | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
 P value | 0.068 | 0.549 | 0.058 | 0.308 | 0.049 | 0.427 | 0.829 | 0.134 | 0.819 | 0.302 | 0.340 | 0.653 |
miR-222G>T | ||||||||||||
 GG | 34.8 ± 3.39 | 21.5 ± 3.09 | 1.3 ± 1.82 | 11.1 ± 1.47 | 29.0 ± 3.20 | 231.6 ± 58.96 | 6.5 ± 1.39 | 15.9 ± 13.67 | 184.9 ± 48.17 | 4.1 ± 1.08 | 10.5 ± 2.71 | 0.8 ± 0.10 |
 GT | 33.3 ± 2.98 | 20.6 ± 2.34 | 0.8 ± 0.87 | 11.1 ± 1.62 | 29.6 ± 3.68 | 240.5 ± 61.10 | 6.8 ± 1.36 | 12.9 ± 5.93 | 195.6 ± 42.44 | 3.8 ± 0.77 | 10.0 ± 2.79 | 0.8 ± 0.10 |
 TT | 34.4 ± 2.13 | 19.5 ± 1.38 | 1.0 ± 1.15 | 11.3 ± 0.63 | 28.3 ± 3.43 | 213.6 ± 33.62 | 5.9 ± 0.88 | 26.8 ± 10.57 | 182.5 ± 28.95 | 3.0 ± 0.30 | 11.3 ± 3.72 | 0.8 ± 0.09 |
 P value | 0.062 | 0.066 | 0.616 | 0.916 | 0.518 | 0.444 | 0.527 | 0.155 | 0.461 | 0.152 | 0.411 | 0.113 |
E2 (Basal) | TSH (mU/L) | FSH (mU/L) | LH (mU/L) | Prolactin (ng/mL) | WBC (103/μl) | Hgb (g/dl) | CD3 (panT) | CD4 (helper T) | CD8 (suppressor) | CD19 (B-cell) | CD56 (NK cell) | |
Mean ± SD (51) | Mean ± SD (93) | Mean ± SD (69) | Mean ± SD (63) | Mean ± SD (94) | Mean ± SD (113) | Mean ± SD (113) | Mean ± SD (92) | Mean ± SD (92) | Mean ± SD (92) | Mean ± SD (92) | Mean ± SD (108) | |
2612.3 ± 2633.01 | 2.3 ± 1.51 | 8.9 ± 4.72 | 4.9 ± 2.40 | 12.6 ± 5.67 | 7.2 ± 3.04 | 12.6 ± 1.39 | 66.0 ± 11.78 | 34.0 ± 8.72 | 29.0 ± 8.22 | 11.2 ± 4.61 | 19.7 ± 9.02 | |
1907.2 ± 1539.73 | 2.2 ± 1.19 | 8.2 ± 3.87 | 4.2 ± 1.75 | 12.9 ± 8.29 | 7.2 ± 2.12 | 12.3 ± 1.51 | 66.9 ± 9.31 | 33.3 ± 8.71 | 28.9 ± 6.43 | 10.2 ± 3.79 | 21.1 ± 11.58 | |
1500.4 | 1.5 | 6.1 | 5.9 | 11.7 | 9.0 | 12.8 | N/A | N/A | N/A | N/A | N/A | |
 | 0.838 | 0.703 | 0.406 | 0.962 | 0.833 | 0.530 | 0.765 | 0.745 | 0.950 | 0.373 | 0.558 | |
2472.7 ± 2463.80 | 2.3 ± 1.56 | 8.7 ± 4.59 | 4.8 ± 2.13 | 12.4 ± 6.08 | 7.2 ± 2.75 | 12.6 ± 1.40 | 65.9 ± 11.82 | 33.4 ± 8.99 | 28.9 ± 8.14 | 11.3 ± 4.89 | 20.3 ± 9.92 | |
2675.4 ± 2485.86 | 2.3 ± 0.80 | 9.1 ± 4.44 | 5.2 ± 2.78 | 14.0 ± 6.69 | 7.4 ± 3.50 | 12.5 ± 1.54 | 66.8 ± 9.58 | 35.8 ± 7.04 | 29.1 ± 6.70 | 10.1 ± 2.21 | 18.8 ± 8.08 | |
25.4 ± 28.43 | 1.400 | 5.9 ± 3.49 | 2.3 ± 1.77 | 6.100 | 7.1 ± 2.73 | 12.7 ± 0.14 | 70.0 ± 9.90 | 34.5 ± 14.85 | 32.5 ± 12.02 | 8.0 ± 1.41 | 22.5 ± 12.02 | |
0.350 | 0.828 | 0.632 | 0.205 | 0.355 | 0.974 | 0.985 | 0.853 | 0.565 | 0.818 | 0.425 | 0.762 | |
2,395.0 ± 2,202.59 | 2.4 ± 1.50 | 8.7 ± 4.65 | 4.8 ± 2.43 | 12.6 ± 6.57 | 7.2 ± 2.92 | 12.7 ± 1.38 | 65.3 ± 11.75 | 33.7 ± 8.33 | 28.8 ± 8.05 | 11.3 ± 4.54 | 20.4 ± 9.31 | |
2812.7 ± 3516.58 | 1.5 ± 0.68 | 8.7 ± 3.90 | 4.8 ± 1.43 | 12.7 ± 4.19 | 7.5 ± 2.63 | 11.9 ± 1.40 | 70.2 ± 7.99 | 34.5 ± 10.33 | 30.2 ± 7.02 | 9.9 ± 3.96 | 18.0 ± 10.85 | |
N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | |
0.730 | 0.019 | 0.985 | 0.920 | 0.968 | 0.668 | 0.031 | 0.106 | 0.732 | 0.501 | 0.260 | 0.342 | |
2475.7 ± 2224.15 | 2.3 ± 1.21 | 7.5 ± 2.58 | 4.5 ± 1.87 | 12.7 ± 6.35 | 7.2 ± 2.83 | 12.4 ± 1.43 | 67.2 ± 8.90 | 32.6 ± 8.90 | 29.9 ± 7.51 | 10.3 ± 3.74 | 20.6 ± 9.91 | |
2553.5 ± 2804.33 | 2.1 ± 1.22 | 10.1 ± 5.93 | 5.3 ± 2.81 | 12.5 ± 6.28 | 7.5 ± 3.06 | 12.7 ± 1.45 | 64.0 ± 15.08 | 35.6 ± 8.12 | 27.2 ± 7.75 | 12.7 ± 5.12 | 19.5 ± 9.79 | |
1784.6 ± 2010.09 | 4.0 ± 4.01 | 10.5 ± 5.15 | 4.8 ± 1.70 | 13.0 ± 4.88 | 5.8 ± 1.33 | 13.0 ± 0.68 | 68.6 ± 5.06 | 35.6 ± 9.09 | 30.3 ± 10.50 | 9.3 ± 4.54 | 18.5 ± 5.21 | |
0.745 | 0.535 | 0.023 | 0.540 | 0.984 | 0.329 | 0.255 | 0.762 | 0.273 | 0.283 | 0.030 | 0.756 |