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Table 6 Stratified analyses of the rs2151280 with lung cancer risks and NSCLC by smoking

From: Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population

Genotyping

Lung cancer

 

Non-small-cell lung cancer

 
 

Controls (%)

Cases (%)

OR (95%CI)

P value

ORª (95%CI)

Pª value

Cases (%)

OR (95%CI)

P value

ORª (95%CI)

Pª value

Never

           

TT

172 (36.1)

121 (41.7)

1.00 (ref)

   

87 (39.7)

1.00 (ref)

   

TC

229 (48.1)

138 (47.6)

0.857 (0.626–1.173)

0.334

0.865 (0.624–1.201)

0.387

107 (48.9)

0.924 (0.654–1.305)

0.653

0.954 (0.665–1.368)

0.798

CC

75 (15.8)

31 (10.7)

0.588 (0.364–0.948)

0.029

0.518 (0.316–0.851)

0.009

25 (11.4)

0.659 (0.391–1.109)

0.117

0.572 (0.334–0.980)

0.042

CC+TC vs TT

 

0.790 (0.586–1.066)

0.123

0.773 (0.567–1.056)

0.106

 

0.858 (0.618–1.193)

0.363

0.850 (0.604–1.197)

0.351

CC vs TC+TT

 

0.640 (0.409–1.000)

0.050

0.561 (0.354–0.891)

0.014

 

0.689 (0.425–1.118)

0.131

0.587 (0.356–0.968)

0.037

T allele

573 (60.2)

380 (65.5)

1.00 (ref)

   

281 (64.2)

1.00 (ref)

   

C allele

379 (39.8)

200 (34.5)

0.796 (0.642–0.986)

0.037

  

157 (35.8)

0.845 (0.668–1.068)

0.158

  

ever

           

TT

31 (47.0)

86 (39.6)

1.00 (ref)

   

66 (37.9)

1.00 (ref)

   

TC

26 (39.4)

106 (48.8)

1.470 (0.812–2.661)

0.204

1.477 (0.762–2.862)

0.248

89 (51.1)

1.608 (0.873–2.961)

0.128

1.812 (0.894–3.673)

0.099

CC

9 (13.6)

25 (11.5)

1.001 (0.421–2.379)

0.998

0.992 (0.378–2.608)

0.987

19 (10.9)

0.992 (0.403–2.440)

0.985

1.025 (0.366–2.872)

0.962

CC+TC vs TT

 

1.349 (0.775–2.349)

0.290

1.351 (0.728–2.508)

0.340

 

1.449 (0.818–2.569)

0.204

1.599 (0.826–3.094)

0.164

CC vs TC+TT

 

0.825 (0.364–1.867)

0.644

0.815 (0.328–2.027)

0.660

 

0.776 (0.332–1.815)

0.559

0.756 (0.287–1.987)

0.570

T allele

88 (66.7)

278 (64.1)

1.00 (ref)

   

221 (63.5)

1.00 (ref)

   

C allele

44 (33.3)

156 (35.9)

1.122 (0.744–1.694)

0.583

  

127 (36.5)

1.149 (0.753–1.754)

0.518

  
  1. OR odds ratio, CI confidence interval, NSCLC non-small-cell lung cancer
  2. aAdjusted for age, gender, and smoking
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Human Genomics

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