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Fig. 7 | Human Genomics

Fig. 7

From: EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway

Fig. 7

RNA-Seq analysis in HCO cells. a Hierarchical cluster heatmap of Z-scores for relevant genes between the sh2 and shNT groups, each of which includes three samples (sh2-1, sh2-2, sh2-3; shNT-1, shNT-2, shNT-3). b GO annotation revealed the most significant enrichment (P < 0.001), among which “cell cycle arrest” and “induction of apoptosis” were directly associated with cell development. c KEGG metabolic pathway categories with a significant P value; the P53 pathway was predicted to be the most likely (P < 0.001). d Protein interactions between EFTUD2 and the P53 pathway determined by the STRING website

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Human Genomics

ISSN: 1479-7364