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Fig. 4 | Human Genomics

Fig. 4

From: EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway

Fig. 4

Zebrafish subjected to eftud2 gene knockout had aberrant cartilage and bone development. a, c Lateral view of larvae treated with eftud2 TALEN mRNA (−/−) at 3 dpf and 5 dpf, exhibiting disruption of cartilage and bone formation compared with WT (+/+). b, d Ventral view of larvae treated with eftud2 TALEN mRNA (−/−) at 3 dpf and 5 dpf, showing cartilage and bone hypoplasia and otolith loss compared with WT (+/+). (The images on the left are WT controls, and those on the right are eftud2 mutants. Black arrows indicate the jawbone. a’ Meckel’s bone. b’ Ceratohyal bone. c’ Parasphenoid. d’ Notochord. e’ Otolith. f’ Ceratobranchial 1–5)

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Human Genomics

ISSN: 1479-7364