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Fig. 1 | Human Genomics

Fig. 1

From: The X chromosome and sex-specific effects in infectious disease susceptibility

Fig. 1

Illustration of the X chromosome indicating the five different strata and chances of genes escaping inactivation within each stratum. Regions lined in red contain the highest densities of immune-associated genes while genes discussed in this review are indicated in green. Genes that contain intragenic miRNA are indicated in black followed by the miRNA number. XIC: X chromosome inactivation centre containing XIST and XACT genes; PAR: Pseudoautosomal region; TLR8: Toll-like receptor 8; TLR7: Toll-like receptor 7; CYBB: Cytochrome b-245, beta polypeptide; AR: Androgen receptor; CXCR3: C–X–C motif chemokine receptor 3; TNFS5: Encodes CD40 ligand; NEMO: NF-kB essential modulator; IRAK1: Interleukin-1 receptor associated kinase 1; HUWE1: HECT, UBA & WWE domain containing 1; GABRA3: Gamma-aminobutyric acid A receptor subunit alpha 3

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