Table 2 Genes expressed in muscle and components of the interactomes of known LGMD genes
Gene | Protein | Interactive partner |
|---|---|---|
ANK1 | ankyrin 1 | RYR1, TTN |
ANKRD23 | ankyrin repeat domain 23 | TTN |
ATP1B4 | ATPase beta 4 polypeptide | POMT1, POMT2 |
C1QTNF9 | C1q and tumor necrosis factor protein 9 | COL6A1, COL6A2 |
C1QTNF9 | C1q and tumor necrosis factor protein 9B | COL6A1, COL6A2 |
EVC2 | Ellis-van Creveld syndrome 2 | TOR1AIP1 |
FYCO1 | FYVE and coiled-coil containing 1 | LMNA |
HECW2 | HECT, C2 and WW containing E3 ubiquitin | DYSF |
HSPB2 | heat shock protein 2 | BAG3, CRYAB, FLNC, TCAP, TTN |
MLIP | muscular LMNA-interacting protein | LMNA |
MYOZ1 | myozenin 1 | FLNC, TCAP |
MYOZ2 | myozenin 2 | FLNC, TCAP |
MYOZ3 | myozenin 3 | FLNC, TCAP |
OPRM1 | opioid receptor mu 1 | TNPO3 |
PDLIM7 | PDZ and LIM domain 7 | BAG3, PLEC |
RXRA | retinoid x receptor alpha | TRIM32 |
SIRT2 | sirtuin 2 | DMD, DNAJB6 |
SRRM2 | serine/arginine repetitive matrix 2 | LMNA, PLEC |
SVIL | Supervillin | LMNA |
TRIM63 | tripartite motif containing 63, E3 ubiquitin protein ligase | DES, FLNC, MYOT, TCAP, TTN |