PAM rs13175330 | Normotensive controls (n = 1610) | HTN group (n = 543) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HTN w/o therapy (n = 377) | HTN w/ therapy (n = 166) | |||||||||||
AA (n = 1377) | G allele (n = 233) | AA (n = 305) | G allele (n = 72) | AA (n = 129) | G allele (n = 37) | |||||||
Systolic BP (mmHg) | 116.2 | ± 0.31 | 117.7 | ± 0.74† | 144.6 | ± 0.68 | 147.9 | ± 1.46* | 123.2 | ± 0.90 | 123.4 | ± 1.70 |
Diastolic BP (mmHg) | 72.6 | ± 0.23 | 73.3 | ± 0.58 | 91.4 | ± 0.45 | 93.8 | ± 1.11* | 75.7 | ± 0.63 | 83.3 | ± 1.67*** |
Triglyceride (mg/dL)a | 119.4 | ± 2.02 | 121.1 | ± 4.29 | 148.2 | ± 5.10 | 163.9 | ± 12.7 | 141.3 | ± 6.79 | 148.4 | ± 9.93 |
Total-cholesterol (mg/dL)a | 198.0 | ± 0.96 | 198.6 | ± 2.53 | 201.7 | ± 2.06 | 194.1 | ± 4.43 | 193.8 | ± 3.01 | 194.5 | ± 5.97 |
HDL-cholesterol (mg/dL)a | 54.0 | ± 0.37 | 53.5 | ± 0.84 | 50.3 | ± 0.73 | 50.4 | ± 1.45 | 50.7 | ± 1.20 | 49.7 | ± 1.98 |
LDL-cholesterol (mg/dL)a | 121.1 | ± 0.88 | 121.1 | ± 2.20 | 122.7 | ± 1.99 | 112.0 | ± 3.71* | 115.5 | ± 2.66 | 115.1 | ± 4.63 |
Glucose (mg/dL)a | 95.5 | ± 0.55 | 96.5 | ± 1.47 | 103.7 | ± 1.49 | 104.8 | ± 3.76 | 105.7 | ± 2.08 | 97.5 | ± 2.56* |
Insulin (μIU/dL)a | 9.07 | ± 0.13 | 9.26 | ± 0.28 | 9.60 | ± 0.33 | 12.1 | ± 0.99** | 9.56 | ± 0.38 | 10.4 | ± 0.79 |
HOMA-IRa | 2.14 | ± 0.04 | 2.21 | ± 0.08 | 2.50 | ± 0.11 | 3.29 | ± 0.41** | 2.45 | ± 0.11 | 2.40 | ± 0.17 |
LDL particle size (nm)a | 23.9 | ± 0.04 | 24.0 | ± 0.06 | 24.0 | ± 0.07 | 23.5 | ± 0.12** | 24.0 | ± 0.09 | 23.9 | ± 0.17 |
Oxidized LDL (U/L)a | 45.9 | ± 0.56 | 47.4 | ± 1.53 | 49.8 | ± 1.27 | 55.0 | ± 2.70* | 43.7 | ± 2.09 | 43.7 | ± 2.85 |