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Fig. 2 | Human Genomics

Fig. 2

From: Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti

Fig. 2

Functional characterization of associated SNPs in CEACAM-1 rs8110904, CEACAM-1 rs8111171, MMP-2 rs1030868, and MMP-2 rs2241145. a Plasma samples from patients with CEACAM-1 rs8110904 genotypes AA (n = 54), AG (n = 87), and GG (n = 59) were analyzed. b Plasma samples from patients with CEACAM-1 rs8111171 genotypes TT (n = 61), GT (n = 77), and GG (n = 61) were analyzed. The GG genotype in both SNPs had significantly higher plasma concentrations of CEACAM-1. c Plasma samples from patients with MMP-2 rs1030868 genotypes AA (n = 50), AG (n = 84), and GG (n = 66) were analyzed. d Plasma samples from patients with MMP-2 rs2241145 genotypes CC (n = 56), CG (n = 91), and GG (n = 53) were analyzed. No significant difference in the plasma levels was seen in the genotypes of either MMP-2 SNP. EDTA Plasma was collected from 101 LE patients and 99 infected patients without disease symptoms for measurement of protein levels of CEACAM-1 and MMP-2. ELISA and quantitative analyses were performed according to the R&D Systems (Wiesbaden, Germany) protocols. The Mann-Whitney test (Statview software version 5.0) was performed to check for differences in plasma concentrations between the genotypes of the indicated SNPs, P < 0.05 considered significant. The black lines indicate the median of the plasma concentrations

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Human Genomics

ISSN: 1479-7364