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Table 2 Past genome-wide association studies of AMD

From: AMD and the alternative complement pathway: genetics and functional implications

Discovered gene/locus Method # Cases/Controls OR Reference
CFH Affymetrix GeneChip Mapping 100K Set of microarrays 96/50 4.6–7.4 [6]
HTRA1/LOC387715 Affymetrix GeneChip Mapping 100K Set of microarrays 99/131 1.66–11.14 [54]
LIPC Affymetrix SNP 6.0 GeneChip and Sequenom 979/1709 0.82 [124]
CETP Affymetrix SNP 6.0 GeneChip and Sequenom 979/1709 1.15 [124]
TIMP3 Illumina Human370 Bead Chips and Illumina Infinium II assay 2157/1150 0.63 [125]
SKIV2L Affymetrix SNP 5.0 GeneChip 1896/1866 0.54 [126]
MYRIP Affymetrix SNP 5.0 GeneChip 1896/1866 0.86 [126]
TNFRSF10A/LOC389641 Illumina Human610-Quad BeadChip and Illumina HumanHap550v3 BeadChip 1536/18894 0.73 [127]
FRK/COL10A1 Affymetrix SNP 6.0 GeneChip and Illumina HumanCNV370v1 Bead Array 2594/4134 0.87 [128]
VEFGA Affymetrix SNP 6.0 GeneChip and Illumina HumanCNV370v1 Bead Array 2594/4134 1.15 [128]
COL8A1/FILIP1L Meta-analysis of GWAS >17000/>60000 1.23 [129]
APOE Meta-analysis of GWAS >17000/>60000   [129]
IER3/DDR1 Meta-analysis of GWAS >17000/>60000 1.16 [129]
SLC16A8 Meta-analysis of GWAS >17000/>60000 1.15 [129]
TGFBR1 Meta-analysis of GWAS >17000/>60000 1.13 [129]
RAD51B Meta-analysis of GWAS >17000/>60000 1.11 [129]
ADAMTS9/MIR548A2 Meta-analysis of GWAS >17000/>60000 1.1 [129]
B3GALTL Meta-analysis of GWAS >17000/>60000 1.1 [129]
  1. Meta-analysis genotyping method/platforms include Illumina HumanHap300, Human610-Quad, HumanHapCNV370, or HumanCNV370v1 BeadChips, Affymetrix 250K Nspl, Illumina Human670-QuadCustom chip, Illumina 660-Quadv1A, Illumina 610-Quad, Illumina Infinium HumanHap300K, HumanHap550v1, or HumanHap550v3 BeadChip, Illumina Infinium II HumanHap550, Affymetrix GeneChip Human Mapping 250k Styl Array, Affymetrix 6.0 or 1M