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Table 2 Past genome-wide association studies of AMD

From: AMD and the alternative complement pathway: genetics and functional implications

Discovered gene/locus

Method

# Cases/Controls

OR

Reference

CFH

Affymetrix GeneChip Mapping 100K Set of microarrays

96/50

4.6–7.4

[6]

HTRA1/LOC387715

Affymetrix GeneChip Mapping 100K Set of microarrays

99/131

1.66–11.14

[54]

LIPC

Affymetrix SNP 6.0 GeneChip and Sequenom

979/1709

0.82

[124]

CETP

Affymetrix SNP 6.0 GeneChip and Sequenom

979/1709

1.15

[124]

TIMP3

Illumina Human370 Bead Chips and Illumina Infinium II assay

2157/1150

0.63

[125]

SKIV2L

Affymetrix SNP 5.0 GeneChip

1896/1866

0.54

[126]

MYRIP

Affymetrix SNP 5.0 GeneChip

1896/1866

0.86

[126]

TNFRSF10A/LOC389641

Illumina Human610-Quad BeadChip and Illumina HumanHap550v3 BeadChip

1536/18894

0.73

[127]

FRK/COL10A1

Affymetrix SNP 6.0 GeneChip and Illumina HumanCNV370v1 Bead Array

2594/4134

0.87

[128]

VEFGA

Affymetrix SNP 6.0 GeneChip and Illumina HumanCNV370v1 Bead Array

2594/4134

1.15

[128]

COL8A1/FILIP1L

Meta-analysis of GWAS

>17000/>60000

1.23

[129]

APOE

Meta-analysis of GWAS

>17000/>60000

 

[129]

IER3/DDR1

Meta-analysis of GWAS

>17000/>60000

1.16

[129]

SLC16A8

Meta-analysis of GWAS

>17000/>60000

1.15

[129]

TGFBR1

Meta-analysis of GWAS

>17000/>60000

1.13

[129]

RAD51B

Meta-analysis of GWAS

>17000/>60000

1.11

[129]

ADAMTS9/MIR548A2

Meta-analysis of GWAS

>17000/>60000

1.1

[129]

B3GALTL

Meta-analysis of GWAS

>17000/>60000

1.1

[129]

  1. Meta-analysis genotyping method/platforms include Illumina HumanHap300, Human610-Quad, HumanHapCNV370, or HumanCNV370v1 BeadChips, Affymetrix 250K Nspl, Illumina Human670-QuadCustom chip, Illumina 660-Quadv1A, Illumina 610-Quad, Illumina Infinium HumanHap300K, HumanHap550v1, or HumanHap550v3 BeadChip, Illumina Infinium II HumanHap550, Affymetrix GeneChip Human Mapping 250k Styl Array, Affymetrix 6.0 or 1M