From: AMD and the alternative complement pathway: genetics and functional implications
Discovered gene/locus | Method | # Cases/Controls | OR | Reference |
---|---|---|---|---|
CFH | Affymetrix GeneChip Mapping 100K Set of microarrays | 96/50 | 4.6–7.4 | [6] |
HTRA1/LOC387715 | Affymetrix GeneChip Mapping 100K Set of microarrays | 99/131 | 1.66–11.14 | [54] |
LIPC | Affymetrix SNP 6.0 GeneChip and Sequenom | 979/1709 | 0.82 | [124] |
CETP | Affymetrix SNP 6.0 GeneChip and Sequenom | 979/1709 | 1.15 | [124] |
TIMP3 | Illumina Human370 Bead Chips and Illumina Infinium II assay | 2157/1150 | 0.63 | [125] |
SKIV2L | Affymetrix SNP 5.0 GeneChip | 1896/1866 | 0.54 | [126] |
MYRIP | Affymetrix SNP 5.0 GeneChip | 1896/1866 | 0.86 | [126] |
TNFRSF10A/LOC389641 | Illumina Human610-Quad BeadChip and Illumina HumanHap550v3 BeadChip | 1536/18894 | 0.73 | [127] |
FRK/COL10A1 | Affymetrix SNP 6.0 GeneChip and Illumina HumanCNV370v1 Bead Array | 2594/4134 | 0.87 | [128] |
VEFGA | Affymetrix SNP 6.0 GeneChip and Illumina HumanCNV370v1 Bead Array | 2594/4134 | 1.15 | [128] |
COL8A1/FILIP1L | Meta-analysis of GWAS | >17000/>60000 | 1.23 | [129] |
APOE | Meta-analysis of GWAS | >17000/>60000 | Â | [129] |
IER3/DDR1 | Meta-analysis of GWAS | >17000/>60000 | 1.16 | [129] |
SLC16A8 | Meta-analysis of GWAS | >17000/>60000 | 1.15 | [129] |
TGFBR1 | Meta-analysis of GWAS | >17000/>60000 | 1.13 | [129] |
RAD51B | Meta-analysis of GWAS | >17000/>60000 | 1.11 | [129] |
ADAMTS9/MIR548A2 | Meta-analysis of GWAS | >17000/>60000 | 1.1 | [129] |
B3GALTL | Meta-analysis of GWAS | >17000/>60000 | 1.1 | [129] |