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Fig. 3 | Human Genomics

Fig. 3

From: Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction reveals mechanisms underlying graft injury and recovery

Fig. 3

Analysis of the intragraft transcriptional network related to the alternative immunosuppression scheme (group 2 patients) after 12 months of follow-up. Network genes were obtained by performing paired comparisons between the intragraft transcriptional profiles (t12 versus t0) of patients submitted to the alternative immunosuppression scheme and by subsequently inputting those genes in the GeneMania tool. a KEGG categories showing enrichment in functions for the network nodes. b Scatterplot of degree versus betweenness centralities for nodes obtained in the transcriptional network analysis. High-hubs, hubs, and bottlenecks are depicted respectively in royal blue, red, and oil blue colors. c Transcriptional subnetwork containing the most central nodes in the group 2 network. Differentially expressed (DE) genes and DE-related genes are represented respectively as gray diamonds and blue circles in the network. Node sizes are based on betweenness centrality measurements. Genes previously associated with the keywords “autophagy,” “extracellular matrix,” “cell adhesion,” and “autoimmunity” are displayed in green color

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Human Genomics

ISSN: 1479-7364