Fig. 1

Mutations in migraine-causing genes. a Single nucleotide substitution at c.4498 A>G, resulting in novel amino acid change M1500V, was found in SCN1A in a patient with FHM (rs121918632, NG_011906.1, Gene ID: 6323). b A novel intronic polymorphism at chr2:16685249, g.77659T>C, c.4581 + 32A>G, located between exons 24 and 25, predicted to affect alternative splicing of SCN1A, in a gene region encoding inactivation loop of sodium channel was found in a patient with MO. c Mutation at c.691T>C, resulting in amino acid change S231P, in KCNK18 (rs363315, NG_028085.1, Gene ID 338567) was found in a patient with MA