From: Whole-genome sequencing targets drug-resistant bacterial infections
Potential target | Location | Target identity | Pathogen | Ref. |
---|---|---|---|---|
mecA/mecC | Chr | Adapter protein/Penicillin-binding protein 2a | MRSA/S. aereus | [184] |
tetM | Chr | Tetracycline resistance protein | Livestock-associated S. aereus CC398 | [157] |
Ï•3/Ï•7 | Chr | Bacteriophages | Human-specific S. aereus CC398 | [157] |
Chp | Chemotaxis inhibitory protein | Â | ||
Scn | Staphylococcal complement inhibitor | |||
Sak | Staphylokinase | |||
gp20 | Chr | Putative prophage DNA transfer protein | Verocytotoxin-producing E. coli O104:H4 | |
impB | Pl | DNA polymerase type Y | ||
usid000007 (contig 69, 14714:14853) | Chr | Sequence positions 47–69 similar to Ricinus communis putative receptor serine-threonine kinase mRNA (XM_002525007.1) | ||
usid000002 (contig 43, 1486:1633) | Chr | Positions 4–34 similar to Pseudomonas putida BIRD-1 major facilitator transporter protein coding sequence (ADR60257.1) | ||
ISAba1 | Chr | Transposase of ISAba1, IS4 family | MDR A. baumannii | |
csuE | Chr | Chaperone-usher pili assembly system | MDR A. baumannii, | [254] |
bla OXA-51 | ||||
BlaOXA-51-like beta-lactamase | GC2 (SG1) | |||
Coding SNP: | Chr | Â | Colistin-resistant K. pneumonia KPNIH1 | [216] |
ind(GA) 321 in KPNIH1_08595 CTG→ATG | Microcin B17 transporter | |||
(L→M) at 130 in KPNIH1_18808 ACC→ATC | Putative membrane protein | |||
(T→I) at 1106 in KPNIH1_07189 GGC→TGC | l-Ala-D/l-Glu epimerase and methyl viologen resistance protein SmvA | |||
(G → C) at 811 in KPNIH1_05438 | Putative transport protein | |||
ampC | Pl/ | β-Lactamase | β-Lactam resistant Enterobacteriaceae and P. aeruginosa | |
ampD | Chr | N-acetylmuramyl-l-alanine amidase, negative regulator of AmpC,AmpD | ||
ampR | HTH-type transcriptional activator AmpR | |||
ampG | Putative transporter | |||
gyrA (Thr83Ile) | Chr | DNA gyrase subunit A | P. aeruginosa resistant to fluoroquinolones | [247] |
parC (Ser87Leu) | DNA topoisomerase 4 subunit A | |||
bla VIM-2 | Pl | Beta-lactamase class B VIM-2 | P. aeruginosa resistant to β-lactams except monobactams | [247] |
aacA29a/aacA29b putative aph ant(4′)-IIb | Chra | 6′-N-aminoglycoside acetyltransferase type I, phosphotransferases | Aminoglycoside resistant P. aeruginosa | [247] |
mexAB-oprM | Chr | Efflux pumps and multidrug resistance operon repressors | MDR P. aeruginosa | [247] |
mexCD-oprJ | ||||
mexEF-oprN | ||||
mexHI-opmD | ||||
mexR | Â | Operons respective regulator Genes | ||
nfxB | ||||
mexT | ||||
mexG | ||||
mexMN | ||||
mexVW | ||||
mexXY | ||||
muxABC-opmB | ||||
emrAB-opmG | ||||
SMR | Small multidrug resistance family of proteins | |||
triABC | Chr | Presence triclosan efflux pump operon | Triclosan resistant P. aeruginosa | [247] |
mexJKL | Resistance nodulation cell division efflux pump | |||
czcCBA | Chr | Cobalt-zinc-cadmium efflux resistance operon | Heavy metal resistant P. aeruginosa | [247] |
pmrAB | Chr | Membrane bound sensor | Colistin and polymyxin resistant P. aeruginosa, S. enterica subsp. Typhimurium, and A. baumannii | |
phoPQ | Chr | Kinases and cytosolic response regulator | ||
60 SNPs | Â | Intergenic regions, enzymes, regulatory and membrane proteins | S. enterica subsp. Enteritidis | |
iniBAC | Drug efflux operon | Â | M.tuberculosis resistant to rifampicin, isoniazid, fluoroquinolone ethambutol, amikacin, para-aminosalicylic acid | [52] |
rpoB (S450L) | ||||
katG (P7 frameshift) gyrB (T500N) | ||||
embB (D1024N) | ||||
rrs (A514C, A1401G) thyA (P17L) |