Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities

Table 2 Studies considering the relationship between degrees of ancestry proportion and asthma and asthma-related outcomes

Study population	Specific phenotype	Study subjects ( n )	Ancestry type	Markers ( n )	Main findings	Reference
AA	Lung function	2,169	Structure	Variable	Increasing Af ancestry associated with lower FEV1 and lower FVC	Kumar et al. [38]
AA	Asthma, exacerbation	392	Structure	59	Increasing Af ancestry associated with increasingly severe asthma exacerbation in males but not females	Rumpel et al. [64]
AA	Smoking/lung function interaction	1,281	Structure	1,332	Increasing Af ancestry associated with lower FEV1 per pack-year of smoking	Aldrich et al. [63]
LA	Asthma severity	362	IBGA	44	Increasing NA ancestry associated with less severe asthma	Salari et al. [56]
Puerto Ricans	Lung function	416	LAMP	85,059	Increasing Af ancestry associated with decreased FEV1 and FVC pre- and post-bronchodilator	Brehm et al. [19]

Modified from Goetz et al. [62]. The structure is model-based clustering method; IBGA is a maximum likelihood-based clustering method, and LAMP is a local ancestry in admixed population inference method.
Af African, Am Amerindian, As Asian, E European, NA Native American, AA African American, LA Latino American, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity.

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