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Table 2 Mapping QGRS orthologs of previously published human G-quadruplexes

From: QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs

Homo sapiens

 

Mus musculus

Gene name

Biological relevance

mRNA (Ref seq)

QGRS location

QGRS sequence motif

Reference

mRNA (Ref seq)

mRNA similarity with human a (%)

QGRS conservation score

LRP5

Receptor-mediated endocytosis

NM_002335.2

3′-UTR (+136)

GGGGTGGGCAGGGCTGGG

Beaudoin et al. 2013 [64]

NM_008513.3

86

1.00

PIM1

Cancer and apoptosis

NM_002648.3

3′-UTR (+279)

GGGGTGGGGGGTGGGGGTGGG

Arora and Suess 2011 [66]

NM_008842.3

52

1.00

IGF2

Wilms' tumor

NM_001127598.1

3′-UTR (+2194)

GGGGTGGGTGGGGGGCAGTGGGGGCTGGGCGGGG

Christiansen et al. 1994 [65]

NM_010514.3

56

1.00

PSD95

Synaptic junction formation

NM_001365.3

3′-UTR (+685)

GGGAGGGAGGGTGGG

Subramanian et al. 2011 [36]

NM_001109752.1

64

1.00

KISS1

Metastasis suppression

NM_002256.3

3′-UTR (+53)

GGGGCGGGGGCGGGGGGCGGGGACGTAGGGCTAAGGGAGGGG

Huijbregts et al. 2012 [67]

NM_178260.3

49

0.706b

NRAS

Rectal cancer

NM_002524.4

5′-UTR (-240)

GGGAGGGGCGGGTCTGGG

Kumari et al. 2007 [24]

NM_010937.2

64

1.00c

ADAM10

Anti-amyloidogenic activity

NM_001110.2

5′-UTR (-78)

GGGGACGGGTATGGGCGGG

Lammich et al. 2011 [31]

NM_007399.3

71

1.00c

MECP2

Rett syndrome/autism

NM_004992.3

5′-UTR (-108)

GGAGGAGGAGGAGGCGAGG

Bagga and D′Antonio 2013 [11]

NM_001081979.1

74

1.00

YY1

Transcription

NM_003403.3

5′-UTR (-203)

GGGCGCGGGCGCACCGAGGCGAGGGAGGCGGG

Huang et al. 2011 [68]

NM_009537.3

89

0.944c

TERF2

Telomeric stabilization

NM_005652.2

5′-UTR (-20)

GGGAGGGCGGGGAGGG

Gomez et al. 2010 [69]

NM_001286200.1

65

1.00

  1. A sampling of human G-quadruplexes reported in the published literature, along with their mouse QGRS orthologs mapped with QGRS-Conserve. (Many of these conserved motifs were also successfully identified in additional mammalian species; data not shown). aValues obtained by semi-global alignments between human and mouse orthologous mRNAs. bRelatively lower conservation score noted due to slight differences in the number of tetrads, loop lengths, and overall lengths of aligned motifs. However, sequence alignment showed high location conservation. cHomologous QGRS mapped upstream of the mouse orthologous mRNA TSS.