New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3

Table 3 Association of MRAS haplotypes with obesity and high low-density lipoprotein levels

Block	Haplotype	Pooled	Cases	Control	χ ²	pvalue
Obesity
1–7	ACCTAAC	0.558	0.541	0.565	4.63	0.031
1–7	ACCTGAC	0.035	0.042	0.031	7.66	0.0056*
1–6	ACCTAA	0.558	0.541	0.564	4.60	0.032
1–6	ACCTGA	0.036	0.044	0.032	8.28	0.004**
2–7	CCTAAC	0.56	0.543	0.567	4.61	0.032
2–7	CCTGAC	0.035	0.042	0.032	6.90	0.0086*
3–7	CTAAC	0.614	0.597	0.618	3.74	0.053
3–7	CTGAC	0.04	0.047	0.036	7.15	0.0075*
1–5	ACCTA	0.558	0.541	0.564	4.36	0.039
1–5	ACCTG	0.037	0.045	0.033	9.22	0.0024**
4–7	TAAC	0.618	0.601	0.623	4.40	0.036
High LDL-cholesterol
1–7	ATTTGAC	0.172	0.153	0.177	4.39	0.036
1–7	CCCGGTT	0.058	0.045	0.060	4.31	0.038
2–7	TTTGAC	0.173	0.152	0.179	5.11	0.024
2–7	CCGGTT	0.062	0.046	0.064	6.27	0.012
1–6	ATTTGA	0.172	0.152	0.177	4.54	0.033
1–5	ATTTG	0.172	0.152	0.176	4.49	0.034
2–6	TTTGA	0.173	0.151	0.178	5.45	0.019
4–7	TAAC	0.618	0.640	0.612	3.61	0.057
4–7	GGTT	0.061	0.048	0.064	4.81	0.028
1–4	ATTT	0.174	0.153	0.179	4.92	0.027
3–6	CTAA	0.613	0.635	0.606	3.79	0.052
3–6	TTGA	0.181	0.158	0.187	6.02	0.014
2–5	TTTG	0.174	0.152	0.179	5.23	0.022
1–3	ATT	0.175	0.154	0.180	5.01	0.025
5–7	AAC	0.620	0.642	0.613	3.78	0.052
2–4	CCT	0.638	0.663	0.632	4.32	0.038

The table shows selected haplotypes constructed from combinations of the studied variants. The most frequent 7-mer haplotype, ACCTAAC (0.558), was employed as the baseline haplotype to determine the relative effects of the associated haplotypes. The minor allele frequency and control and case haplotype frequencies are proportions. Number 1 denotes rs1199338_AC, 2 is rs166195_CT, 3 is rs253662_CT, 4 is rs1720819_TG, 5 is rs6782181_AG, 6 is rs3732837_AT and 7 is rs9818870_CT, arranged sequentially by their chromosomal positions, and blocks represent the variant constituting the respective haplotypes. *p < 0.01; **p < 0.005 by the χ² test.

ISSN: 1479-7364