A useful tool for drug interaction evaluation: The University of Washington Metabolism and Transport Drug Interaction Database

Table 1 Metabolism and Transport Drug Interaction Database (DIDB) users

Institution	Group	Examples of database use
Pharmaceutical industry & CROs	DMPK Clinical pharmacology Clinical	Tool for IVIVE Modelling: to define acceptable input parameters and validate models
		Helps optimize design of in vitro and in vivo drug interaction studies
		Provides context for results obtained for candidate compounds
		Provides access to labelling of recently marketed drugs
		DIDB as a research tool: publications - Presentations
Regulatory agencies	Reviewers	Provides context for results submitted for candidate compounds
		Helps update guidance documents (DDI, pharmacogenetics)
		DIDB as a research tool: publications - presentations
Academia	Metabolism	Didactic tool
	Pharmacokinetics	Resource for courses on DDI
	Clinical pharmacology	DIDB as a research tool: publications - presentations

CRO, contract research organisation; DDI, drug-drug interaction; DMPK, drug metabolism and pharmacokinetics.

ISSN: 1479-7364