Table 1 Human IL and IL-related cytokines.
From: Evolutionary divergence and functions of the human interleukin (IL) gene family
Gene | Full gene name | Aliases | Human | ||||
|---|---|---|---|---|---|---|---|
| Â | Â | Â | Chromosome | Isoforms | Ref seq mRNA number | Ref seq protein number | AA# |
IL1A | Interleukin 1, alpha | IL1F1, IL1A, IL-1A, IL1, IL1-ALPHA | 2q14 | Â | NM_000575.3 | NP_000566.3 | 270 |
IL1B | Interleukin 1, beta | IL1F2, IL1B, IL-1, IL1-BETA | 2q14 | Â | NM_000576.2 | NP_000567.1 | 268 |
IL1RN | Interleukin 1 receptor antagonist | DIRA, IRAP , IL1F3, IL1RA, MVCD4, IL1RN, IL1ra, IL1ra3, ICIL1RA, MGC10430, ICIL-1RA, IL-1RN | 2q14.2 | Â | NM_173842.2 | NP_776214.1 | 177 |
IL1F5 | Interleukin 1 family, member 5 | UNQ1896/PRO4342, FIL1, FIL1(DELTA), FIL1D, IL1HY1, IL1L1, IL1RP3, MGC29840 | 2q14 | Â | NM_173170.1 | NP_775262.1 | 154 |
IL1F6 | Interleukin 1 family, member 6 | FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), MGC129552, MGC129553 | 2q12-q14.1 | Â | NM_014440.1 | NP_055255.1 | 157 |
IL1F7 | Interleukin 1 family, member 7 | FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H4, IL-1RP1, IL1H4, IL1RP1 | 2q12-q14. 1 | Isoform 1 | NM_014439.3 | NP_055254.2 | 217 |
| Â | Â | Â | Â | Isoform 2 | NM_173202.1 | NP_775294.1 | 197 |
| Â | Â | Â | Â | Isoform 3 | NM_173203.1 | NP_775295.1 | 157 |
| Â | Â | Â | Â | Isoform 4 | NM_173204.1 | NP_775296.1 | 178 |
| Â | Â | Â | Â | Isoform 5 | NM_173205.1 | NP_775297.1 | 192 |
IL1F8 | Interleukin 1 family, member 8 | FIL1, FIL1-(ETA), FIL1H, IL-1F8, IL-1H2, IL1-ETA, IL1H2, MGC126880, MGC126882 | 2q14 | Â | NM_014438.3 | NP_055253.2 | 163 |
IL1F9 | Interleukin 1 family, member 9 | UNQ2456/PRO5737, IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1H1, IL1RP2 | 2q12-q21 | Â | NM_019618.2 | NP_062564.1 | 168 |
IL1F10 | Interleukin 1 family, member 10 | FKSG75, FIL1-theta, IL-1HY2, IL1-theta, MGC119831, MGC119832, MGC119833 | 2q13 | Â | NM_032556.4 | NP_115945.4 | 151 |
IL2 | Interleukin 2 | IL-2, TCGF , lymphokine | 4q26-q27 | Â | NM_000586.3 | NP_000577.2 | 152 |
IL3 | Interleukin 3 | IL-3, MCGF , MGC79398, MGC79399, MULTI-CSF | 5q23-q31 | Â | NM_000588.3 | NP_000579.2 | 151 |
IL4 | Interleukin 4 | BCGF-1, BCGF1, BSF1, IL-4, MGC79402 | 5q23-q31 | Isoform 1 | NM_000589.2 | NP_000580.1 | 152 |
| Â | Â | Â | Â | Isoform 2 | NM_172348.1 | NP_758858.1 | 137 |
| Â | Â | Â | Â | Isoform 2 | NM_172348.1 | NP_758858.1 | 137 |
IL5 | Interleukin 5 | EDF, IL-5, TRF | 5q23-q31 | Â | NM_000879.2 | NP_000870.1 | 133 |
IL6 | Interleukin 6 | BSF2, HGF, HSF , IFNB2, IL-6 | 7p21 | Â | NM_000600.3 | NP_000591.1 | 211 |
IL7 | Interleukin 7 | IL-7 | 8q12-q13 | Â | NM_000880.2 | NP_000871.1 | 176 |
IL8 | Interleukin 8 | CXCL8, GCP-1, GCP1, LECT, LUCT , LYNAP, MDNCF , MONAP, NAF , NAP-1, NAP1 | 4q13-q21 | Â | NM_000584.2 | NP_000575.1 | 98 |
IL9 | Interleukin 9 | HP40, IL-9, P40 | 5q31-q35 | Â | NM_000590.1 | NP_000581.1 | 143 |
IL10 | Interleukin 10 | RP11-262N9.1, CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF | 1q31-q32 | Â | NM_000572.2 | NP_000563.1 | 177 |
IL11 | Interleukin 11 | AGIF, IL-11 | 19q13.3-q13.4 | Â | NM_000641.2 | NP_000632.1 | 198 |
IL12A | Interleukin 12A | CLMF, IL-12A, NFSK, NKSF1, P35 | 3q25.33-q26 | Â | NM_000882.2 | NP_000873.2 | 252 |
IL13 | Interleukin 13 | ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600 | 5q31 | Â | NM_002188.2 | NP_002179.2 | 145 |
TXLNA | Taxilin alpha | IL14, DKFZp451J0118, MGC118870, MGC118871, RP4-622L5.4, TXLN | 1p35.1 | Â | NM_175852.3 | NP_787048.1 | 546 |
IL15 | Interleukin 15 | IL-15, MGC9721 | 4q31 | Â | NM_001044731.1 | NP_000576.1 | 161 |
IL16 | Interleukin 16 | FLJ16806, FLJ42735, FLJ44234, LCF , NIL16, PRIL16, prIL-16 | 15q26.3 | Isoform 1 | NM_004513.5 | NP_004504.3 | 631 |
| Â | Â | Â | Â | Isoform 2 | NM_172217.3 | NP_757366.2 | 1332 |
| Â | Â | Â | Â | Isoform 3 | NM_001172128.1 | NP_001165599.1 | 1331 |
IL17A | Interleukin 17A | CTLA8, IL-17, IL-17A, IL17 | 6p12 | Â | NM_002190.2 | NP_002181.1 | 154 |
IL17B | Interleukin 17B | UNQ516/PRO1031, IL-17B, IL-20, MGC138900, MGC138901, ZCYTO7 | 5q33.1 | Â | NM_014443.2 | NP_055258.1 | 179 |
IL17C | Interleukin 17C | UNQ561/PRO1122, CX2, IL-17C, IL-21, MGC126884, MGC138401 | 16q24 | Â | NM_013278.3 | NP_037410.1 | 196 |
IL17D | Interleukin 17D | IL-22, IL-27, IL-17D, FLJ30846 | 13q11 | Â | NM_138284.1 | NP_612141.1 | 201 |
IL17F | Interleukin 17F | IL-17F, ML-1, ML1 | 6p12 | Â | NM_052872.3 | NP_443104.1 | 162 |
IL18 | Interleukin 18 | IGIF, IL1F4, IL-18, IL-1g, MGC12320 | 11q22.2-q22.3 | Â | NM_001562.2 | NP_001553.1 | 192 |
IL19 | Interleukin 19 | RP11-262N9.2, IL-10C, MDA1, NG.1, ZMDA1 | 1q32.2 | Isoform 1 | NM_153758.1 | NP_715639.1 | 214 |
| Â | Â | Â | Â | Isoform 2 | NM_013371.2 | NP_037503.2 | 177 |
IL20 | Interleukin 20 | UNQ852/PRO1801, IL-20, IL10D, MGC96907, ZCYTO10 | 1q32 | Â | NM_018724.3 | NP_061194.2 | 175 |
IL21 | Interleukin 21 | Za11, IL-21 | 4q26-q27 | Â | NM_021803.2 | NP_068575.1 | 161 |
IL22 | Interleukin 22 | UNQ3099/PRO10096, IL-21, IL-22, IL-D110, IL-TIF, IL21, ILTIF , MGC79382, MGC79384, TIFIL-23, TIFa, zcyto18 | 12q15 | Â | NM_020525.4 | NP_065386.1 | 178 |
IL23A | Interleukin 23A | UNQ2498/PRO5798, IL23, IL-23A, IL23P19, MGC79388, P19, SGRF | 12q13.13 | Â | NM_016584.2 | NP_001717165.2 | 205 |
IL24 | Interleukin 24 | C49A, FISP, IL10B, MDA7, MOB5, ST16 | 1q32 | Isoform 1 | NM_006850.2 | NP_006841.1 | 205 |
| Â | Â | Â | Â | Isoform 3 | NM_001185156.1 | NP_001172085.1 | 207 |
| Â | Â | Â | Â | Isoform 4 | NM_001185157.1 | NP_001172086.1 | 154 |
| Â | Â | Â | Â | Isoform 5 | NM_001185158.1 | NP_001172087.1 | 63 |
IL25 | Interleukin 25 | UNQ3120/PRO10272, IL17E | 14q11.2 | Isoform 1 | NM_022789.3 | NP_073626.1 | 176 |
| Â | Â | Â | Â | Isoform 2 | NM_172314.1 | NP_758525.1 | 161 |
IL26 | Interleukin 26 | AK155, IL-26 | 12q15 | Â | NM_018402.1 | NP_060872.1 | 170 |
IL27A | Interleukin 27 | IL-27, IL-27A, IL27p28, IL30, MGC71873, p28 | 16p11 | Â | NM_145659.3 | NP_663634.2 | 242 |
IL28A | Interleukin 28A | IFNL2, IL-28A | 19q13.13 | Â | NM_172138.1 | NP_742150.1 | 199 |
IL28B | Interleukin 28B | IFNL3, IL-28B, IL28C | 19q13.13 | Â | NM_172139.2 | NP_742151.2 | 195 |
IL29 | Interleukin 29 | IFNL1, IL-29 | 19q13.13 | Â | NM_172140.1 | NP_742152.1 | 200 |
IL31 | Interleukin 31 | IL-31 | 12q24.31 | Â | NM_001014336.1 | NP_001014358.1 | 164 |
IL32 | Interleukin 32 | IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd | 16p13.3 | Isoform a | NM_001012633.1 | NP_001012651.1 | 131 |
| Â | Â | Â | Â | Isoform b | NM_001012631.1 | NP_001012649.1 | 188 |
| Â | Â | Â | Â | Â | NM_001012632.1 | NP_001012650.1 | Â |
| Â | Â | Â | Â | Â | NM_001012718.1 | NP_001012736.1 | Â |
| Â | Â | Â | Â | Â | NM_004221.4 | NP_004212.4 | Â |
| Â | Â | Â | Â | Isoform c | NM_001012634.1 | NP_001012652.1 | 168 |
| Â | Â | Â | Â | Â | NM_001012635.1 | NP_001012653.1 | Â |
| Â | Â | Â | Â | Isoform d | NM_001012636.1 | NP_001012654.1 | 179 |
IL33 | Interleukin 33 | IL1F11, C9orf26, DKFZp586H0523, DVS27, NF-HEV , NFEHEV , RP11-575C20.2 | 9p24.1 | Â | NM_033439.2 | NP_254274.1 | 270 |
IL34 | Interleukin 34 | C16orf77, IL-34, MGC34647 | 16q22.1 | Â | NM_001172772.1 | NP_001166243.1 | 242 |
CNTF | Ciliary neurotrophic factor | HCNTF | 11q12.2 | Â | NM_000614.3 | NP_000605.1 | 200 |
CTF1 | Cardiotrophin 1 | CT1, CT-1 | 16p11.2 | Isoform 1 | NM_001330.3 | NP_001321.1 | 201 |
| Â | Â | Â | Â | Isoform 2 | NM_001142544.1 | NP_001136016.1 | 200 |
CLCF1 | Cardiotrophin-like cytokine factor 1 | CLC, NR6, BSF3, NNT1, BSF-3, CISS2, NNT-1 | 11q13.3 | Isoform 1 | NM_013246.2 | NP_037378.1 | 225 |
| Â | Â | Â | Â | Isoform 2 | NM_001166212.1 | NP_001159684.1 | 215 |
CSF1 | Colony-stimulating factor 1 | MCSF, MGC31930 | 1p21-p13 | Isoform 1 | NM_000757.4 | NP_000748.3 | 554 |
| Â | Â | Â | Â | Isoform 2 | NM_172210.2 | NP_757349.1 | 438 |
CSF2 | Colony-stimulating factor 2 | GMCSF , MGC131935, MGC138897, GM-CSF | 5q31.1 | Â | NM_000758.2 | NP_000749.2 | 144 |
CSF3 | Colony-stimulating factor 3 | GCSF, CSF3OS, C17orf33, MGC45931 | 17q11.2-q12 | Isoform a | NM_000759.3 | NP_000750.1 | 207 |
| Â | Â | Â | Â | Isoform b | NM_172219.2 | NP_757373.1 | 204 |
| Â | Â | Â | Â | Isoform c | NM_172220.2 | NP_757374.2 | 171 |
| Â | Â | Â | Â | Isoform d | NM_001178147.1 | NP_001171618.1 | 168 |
LIF | Leukaemia inhibitory factor | CDF, DIA, HILDA | 22q12.2 | Â | NM_002309.3 | NP_002300.1 | 202 |
OSM | Oncostatin M | MGC20461 | 22q12.2 | Â | NM_020530.3 | NP_065391.1 | 252 |
TSLP | Thymic stromal lymphopoietin | TSLP | 5q22.1 | Â | NM_033035.4 | NP_149024.1 | 159 |