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Table S1 Function and regulation of eukaryotic small subunit ribosomal proteins

From: The other lives of ribosomal proteins

Protein Name Organism Function Reference Find online at:
RPSA Porcine Candidate for binding and internalisation of externally added cellular prion protein in the gut Knorr, C., Beuermann, C., Beck, J. and Brenig, B. (2007), 'Characterization of the porcine multicopy ribosomal protein SA/37-kDa laminin receptor gene family', Gene Vol. 395(1-2), pp. 135-143. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/17434268
RPS3A Human Cell apoptosis regulation Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/10361251
RPS6 Drosophila homologue of human S6 Tumour suppressor in the haematopoietic system Watson, K.L., Konrad, K.D., Woods, D.F. and Bryant, P.J. (1992), 'Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Proc. Natl. Acad. Sci. USA Vol. 89, pp. 11302-11306. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=50538
RPS7 Zebrafish Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pbio.0020139&ct=1
RPS8 Zebrafish Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pbio.0020139&ct=1
RPS9 Human Involved in retinal formation Uechi, T., Tanaka, T. and Kenmochi, N. (2001), 'Complete map of the human ribosomal protein genes: Assignment of 80 genes to the cytogenetic map and implications for human disorders', Genomics Vol. 72, pp. 223-230. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/11401437
RPS10 Arabidopsis thaliana Developmental regulation Majewski, P., Wołoszyńska, M. and Janńska, H. (2009), 'Developmentally early and late onset of Rps10 silencing in Arabidopsis thaliana: Genetic and environmental regulation', J. Exp. Bot. Vol. 60, pp. 1163-1178. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2657537&tool=pmcentrez
RPS13 Human Cell growth or proliferation regulation Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683
RPS15 Drosophila Overexpression of S15a suppresses a utation in the Saccharomyces cerevisiae cdc33 gene, which encodes the cap-binding subunit of eukaryotic initiation factor 4F (eIF-4F); mutations of cdc33 lead to arrest in the cell cycle at the G1 to S transition. Saeboe-Larssen, S. and Lambertsson, A. (1996), 'A novel Drosophila Minute locus encodes ribosomal protein S13', Genetics Vol. 143, pp. 877-885. http://www.genetics.org/cgi/reprint/143/2/877
  Human Role in nuclear export of 40S subunit precursors Gazda, H., Sheen, M.R., Vlachos, A., Choesmel, V. et al. (2008), 'Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients', Am. J. Hum. Genet. Vol. 83, pp. 769-780. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/19061985
RPS15A Zebrafish Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397
RPS18 Arabidopsis thaliana Developmental regulation Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683
  Arabidopsis thaliana Mutation in S18 associated with growth retardation and abnormal leaf development Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/10361251
  Zebrafish Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397
RPS19 Ascaris lumbricoides Developmental regulation Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683
  Human Tumour progression, invasion, metastasis, differentiation' Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683
  Human Degeneration of retina Uechi, T., Tanaka, T. and Kenmochi, N. (2001), 'Complete map of the human ribosomal protein genes: Assignment of 80 genes to the cytogenetic map and implications for human disorders', Genomics Vol. 72, pp. 223-230. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/11401437
  Human Dimer acts as a monocyte chemotactic factor in phagocytic clearance of apoptotic cells Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/10361251
  Zebrafish Haematopoietic and developmental abnormalities Danilova, N., Sakamoto, K.M. and Lin, S. et al. (2008), 'Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family', Blood Vol. 112, pp. 5228-5537. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/18515656
RPS20 Yeast Overexpression of S20 suppresses temperature-sensitive RNA pol III (but no specificity?) Hermann-Le Denmat, S., Sipiczki, M. and Thuriaux, P. (1994), 'Suppression of yeast RNA polymerase III mutations by the URP2 gene encoding a protein homologous to the mammalian ribosomal protein S20', J. Mol. Biol. Vol. 240, pp. 1-7. http://0-www.sciencedirect.com.brum.beds.ac.uk/science?_ob=ArticleURL&_udi=B6WK7-45PV62P-1S&_user=4887109&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000062864&_version=1&_urlVersion=0&_userid=4887109&md5=88a77e1986f7765e9374d649cc9b23a8
  Human mRNA downregulated in onset of apoptosis in leukaemic cells Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/10361251
RPS21 Drosophila Acts as a translation initiation factor rather than as a core ribosomal protein Török, I., Herrmann-Horle, D., Kiss, I., Tick, G. et al. (1999), 'Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs', Mol. Cell Biol. Vol. 19, pp. 2308-2321. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=84023&tool=pmcentrez
RPS27A Human Cell growth or proliferation regulation Ye, J.L. and Zhang, Y.Z. (2007), 'The connection between tumor and ubiquitin-ribosomal protein S27a, ubiquitin and ribosomal protein', Sheng Wu Gong Cheng Xue Bao Vol. 23, pp. 982-988. [Article in Chinese] http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/18257223?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
  Human Cell growth or proliferation regulation Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683
  Human Cell malignant transformation Ye, J.L. and Zhang, Y.Z. (2007), 'The connection between tumor and ubiquitin-ribosomal protein S27a, ubiquitin and ribosomal protein', Sheng Wu Gong Cheng Xue Bao Vol. 23, pp. 982-988. [Article in Chinese] http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/18257223?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
RPS28 Yeast Binds to the 3' UTR of its mRNA to stimulate its deadenylation and degradation Badis, G., Saveanua, C., Fromont-Racinea, M. and Jacquie, A. (2004), 'Targeted mRNA degradation by deadenylation-independent decapping', Mol. Cell Vol. 15, pp. 5-15. http://0-www.sciencedirect.com.brum.beds.ac.uk/science?_ob=ArticleURL&_udi=B6WSR-4CRXKG3-3&_user=4887109&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000062864&_version=1&_urlVersion=0&_userid=4887109&md5=9b5ba025da819e725850644ba547d47c
RPS29 Human Tumour suppression gene regulation Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683
  Human Increases tumour supporessor activity of Krev-1' Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/10361251
  Zebrafish Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397
  1. Date last accessed for all websites is 17th June, 2010