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Table S1 Function and regulation of eukaryotic small subunit ribosomal proteins

From: The other lives of ribosomal proteins

Protein Name

Organism

Function

Reference

Find online at:

RPSA

Porcine

Candidate for binding and internalisation of externally added cellular prion protein in the gut

Knorr, C., Beuermann, C., Beck, J. and Brenig, B. (2007), 'Characterization of the porcine multicopy ribosomal protein SA/37-kDa laminin receptor gene family', Gene Vol. 395(1-2), pp. 135-143.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/17434268

RPS3A

Human

Cell apoptosis regulation

Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/10361251

RPS6

Drosophila homologue of human S6

Tumour suppressor in the haematopoietic system

Watson, K.L., Konrad, K.D., Woods, D.F. and Bryant, P.J. (1992), 'Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Proc. Natl. Acad. Sci. USA Vol. 89, pp. 11302-11306.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=50538

RPS7

Zebrafish

Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans

Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139.

http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pbio.0020139&ct=1

RPS8

Zebrafish

Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans

Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139.

http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pbio.0020139&ct=1

RPS9

Human

Involved in retinal formation

Uechi, T., Tanaka, T. and Kenmochi, N. (2001), 'Complete map of the human ribosomal protein genes: Assignment of 80 genes to the cytogenetic map and implications for human disorders', Genomics Vol. 72, pp. 223-230.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/11401437

RPS10

Arabidopsis thaliana

Developmental regulation

Majewski, P., Wołoszyńska, M. and Janńska, H. (2009), 'Developmentally early and late onset of Rps10 silencing in Arabidopsis thaliana: Genetic and environmental regulation', J. Exp. Bot. Vol. 60, pp. 1163-1178.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2657537&tool=pmcentrez

RPS13

Human

Cell growth or proliferation regulation

Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683

RPS15

Drosophila

Overexpression of S15a suppresses a utation in the Saccharomyces cerevisiae cdc33 gene, which encodes the cap-binding subunit of eukaryotic initiation factor 4F (eIF-4F); mutations of cdc33 lead to arrest in the cell cycle at the G1 to S transition.

Saeboe-Larssen, S. and Lambertsson, A. (1996), 'A novel Drosophila Minute locus encodes ribosomal protein S13', Genetics Vol. 143, pp. 877-885.

http://www.genetics.org/cgi/reprint/143/2/877

 

Human

Role in nuclear export of 40S subunit precursors

Gazda, H., Sheen, M.R., Vlachos, A., Choesmel, V. et al. (2008), 'Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients', Am. J. Hum. Genet. Vol. 83, pp. 769-780.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/19061985

RPS15A

Zebrafish

Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans

Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397

RPS18

Arabidopsis thaliana

Developmental regulation

Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683

 

Arabidopsis thaliana

Mutation in S18 associated with growth retardation and abnormal leaf development

Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/10361251

 

Zebrafish

Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans

Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397

RPS19

Ascaris lumbricoides

Developmental regulation

Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683

 

Human

Tumour progression, invasion, metastasis, differentiation'

Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683

 

Human

Degeneration of retina

Uechi, T., Tanaka, T. and Kenmochi, N. (2001), 'Complete map of the human ribosomal protein genes: Assignment of 80 genes to the cytogenetic map and implications for human disorders', Genomics Vol. 72, pp. 223-230.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/11401437

 

Human

Dimer acts as a monocyte chemotactic factor in phagocytic clearance of apoptotic cells

Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/10361251

 

Zebrafish

Haematopoietic and developmental abnormalities

Danilova, N., Sakamoto, K.M. and Lin, S. et al. (2008), 'Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family', Blood Vol. 112, pp. 5228-5537.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/18515656

RPS20

Yeast

Overexpression of S20 suppresses temperature-sensitive RNA pol III (but no specificity?)

Hermann-Le Denmat, S., Sipiczki, M. and Thuriaux, P. (1994), 'Suppression of yeast RNA polymerase III mutations by the URP2 gene encoding a protein homologous to the mammalian ribosomal protein S20', J. Mol. Biol. Vol. 240, pp. 1-7.

http://0-www-sciencedirect-com.brum.beds.ac.uk/science?_ob=ArticleURL&_udi=B6WK7-45PV62P-1S&_user=4887109&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000062864&_version=1&_urlVersion=0&_userid=4887109&md5=88a77e1986f7765e9374d649cc9b23a8

 

Human

mRNA downregulated in onset of apoptosis in leukaemic cells

Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/10361251

RPS21

Drosophila

Acts as a translation initiation factor rather than as a core ribosomal protein

Török, I., Herrmann-Horle, D., Kiss, I., Tick, G. et al. (1999), 'Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs', Mol. Cell Biol. Vol. 19, pp. 2308-2321.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=84023&tool=pmcentrez

RPS27A

Human

Cell growth or proliferation regulation

Ye, J.L. and Zhang, Y.Z. (2007), 'The connection between tumor and ubiquitin-ribosomal protein S27a, ubiquitin and ribosomal protein', Sheng Wu Gong Cheng Xue Bao Vol. 23, pp. 982-988. [Article in Chinese]

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/18257223?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 

Human

Cell growth or proliferation regulation

Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683

 

Human

Cell malignant transformation

Ye, J.L. and Zhang, Y.Z. (2007), 'The connection between tumor and ubiquitin-ribosomal protein S27a, ubiquitin and ribosomal protein', Sheng Wu Gong Cheng Xue Bao Vol. 23, pp. 982-988. [Article in Chinese]

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/18257223?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

RPS28

Yeast

Binds to the 3' UTR of its mRNA to stimulate its deadenylation and degradation

Badis, G., Saveanua, C., Fromont-Racinea, M. and Jacquie, A. (2004), 'Targeted mRNA degradation by deadenylation-independent decapping', Mol. Cell Vol. 15, pp. 5-15.

http://0-www-sciencedirect-com.brum.beds.ac.uk/science?_ob=ArticleURL&_udi=B6WSR-4CRXKG3-3&_user=4887109&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000062864&_version=1&_urlVersion=0&_userid=4887109&md5=9b5ba025da819e725850644ba547d47c

RPS29

Human

Tumour suppression gene regulation

Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683

 

Human

Increases tumour supporessor activity of Krev-1'

Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205.

http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/pubmed/10361251

 

Zebrafish

Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans

Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397

  1. Date last accessed for all websites is 17th June, 2010