Genes | Simulated causal intermediate variable (β = 2 per SD) | |||
---|---|---|---|---|
 | Homocysteine concentration | Pyrimidine synthesis (TS) | Purine synthesis (AICART) | DNA methylation (DNMT) |
1. DHFR | 1.012 | 0.963 | 0.978 | 0.988 |
2. TS | 0.910*** | 0.437*** | 1.129*** | 1.103*** |
3. MTD | 0.753*** | 2.451*** | 0.540*** | 1.659*** |
4. MTCH | 0.793*** | 1.805*** | 0.532*** | 1.372*** |
5. PGT | 1.059 | 0.863** | 0.200*** | 0.950 |
6. AICART | 1.044 | 0.989 | 0.972 | 0.963 |
7. FTD | 0.969 | 1.009 | 0.713*** | 1.077* |
8. FTS | 1.048 | 0.899*** | 1.709*** | 0.957 |
9. SHMT | 1.256*** | 0.558*** | 0.592*** | 0.639*** |
10. MTHFR | 1.298*** | 1.073* | 1.153*** | 0.573*** |
11. MS | 1.197*** | 0.790*** | 0.736*** | 0.815*** |
12. SAHH | 0.428*** | 1.097** | 1.108** | 0.564*** |
13. CBS | 2.753*** | 1.073* | 1.028 | 0.925* |
14. MAT-II | 0.998 | 1.013 | 1.014 | 0.999 |
Exposures | ||||
1. Intracellular folate | 0.790*** | 1.783*** | 1.961*** | 1.543*** |
2. Methionine intake | 3.819*** | 1.226*** | 1.112** | 1.342*** |