Skip to main content

Advertisement

Table S4 Results from simulations in which the relationship between FEV and confounders was determined by published FEV prediction equations and phenotype data was truncated to exclude individuals with PPFEV ≤80 percent

From: Recommendations for using standardised phenotypes in genetic association studies

N Heritability Allele frequency Power in population-based design (%) Power in family-based design (%) Avg. R2 (%)
    FEV PPFEV FEV adj. PPFEV adj. FEV PPFEV FEV adj. PPFEV adj. FEV adj. PPFEV adj.
100 0.01 0.05 6.5 14.6 15.2 15.3 4.6 8.5 8.6 8.2 85.5 7.5
   0.1 5.8 14.3 14.4 15.1 5.5 8.8 8.9 8.5 85.5 7.6
   0.2 6.1 13.8 14.7 14.6 5.6 9.4 9.4 9.2 85.4 7.9
  0.025 0.05 8.8 30.4 31.2 31.5 5.9 14.3 14.3 13.9 85.3 7.7
   0.1 8.4 29.5 30.5 30.3 6.6 15.8 15.8 15.5 85.3 7.9
   0.2 7.7 28.5 29.5 29.4 6.3 15.7 15.6 15.1 85.3 8.0
  0.05 0.05 12.2 52.6 53.8 53.8 7.3 24.7 23.9 24.0 84.9 7.8
   0.1 11.7 52.8 54.4 53.6 7.6 26.9 26.9 26.2 84.9 8.1
   0.2 10.7 50.8 52.9 52.5 7.8 27.5 27.5 26.9 84.9 8.3
400 0.01 0.05 10.1 41.6 43.1 42.3 6.9 22.3 22.7 22.2 85.2 4.3
   0.1 9.2 41.5 42.9 41.9 6.8 22.9 23.0 23.0 85.1 4.3
   0.2 8.7 40.1 40.7 40.3 6.7 23.1 23.2 22.9 85.1 4.4
  0.025 0.05 17.3 79.8 81.8 80.8 10.4 48.3 49.1 48.0 85.0 4.3
   0.1 16.5 79.8 81.6 80.5 10.2 49.1 50.0 48.7 85.0 4.5
   0.2 16.6 78.5 80.0 78.8 10.2 48.0 49.4 47.9 84.9 4.6
  0.05 0.05 32.0 97.6 98.4 97.8 17.0 77.1 78.5 77.2 84.6 4.5
   0.1 30.3 97.4 98.2 97.7 17.1 78.5 80.0 78.4 84.6 4.7
   0.2 29.2 97.7 98.3 97.9 16.9 78.5 80.4 78.6 84.5 4.9
800 0.01 0.05 13.9 69.6 72.1 69.9 9.5 40.2 41.2 40.1 85.1 3.6
   0.1 13.1 68.3 69.9 68.4 8.7 40.5 41.8 40.5 85.1 3.7
   0.2 13.4 67.8 70.5 68.2 8.7 39.7 41.3 40.1 85.1 3.8
  0.025 0.05 30.2 97.1 97.9 97.3 16.6 77.3 79.1 77.6 84.9 3.7
   0.1 27.7 97.3 98.1 97.3 15.5 78.0 79.7 78.1 84.9 3.8
   0.2 26.5 96.8 97.8 96.8 15.5 78.4 80.5 78.7 84.8 4.0
  0.05 0.05 55.6 99.7 100.0 99.7 30.9 96.4 97.5 96.5 84.6 3.9
   0.1 52.1 99.6 100.0 99.6 29.6 97.1 98.0 97.3 84.5 4.0
   0.2 51.4 99.6 100.0 99.6 29.3 96.8 97.9 97.0 84.5 4.3
  1. FEV, forced expiratory volume; PPFEV, percentage of predicted FEV.