Skip to main content
Figure 1 | Human Genomics

Figure 1

From: A genome-wide survey of segmental duplications that mediate common human genetic variation of chromosomal architecture

Figure 1

Pair-wise alignments using the ICAass algorithm and our adaptation of Miropeats (reducing redundancy and clarifying alignments via colouration) revealing a high degree of sequence similarity and structure between the chromosome 8p23 inversion region and duplicated segments from other chromosomes. Coloured lines depict the degree of alignment; darker coloured lines represent longer alignments. Colours range from yellow (< 100 bp of sequence) through to orange, cyan, purple, green, red, blue and black (> 4 kb of sequence). The arrows indicate the relative orientation of the repeats at the different loci. Figures 1a and 1b show the alignment from the 8p23 inversion region, with sequences from 4p16 and 11q13, respectively, showing the entirety of the segmental duplications in opposite orientation with respect to chromosome 8p23 low-copy repeats. Figure 1c shows a similar alignment, with sequences from 3q21 revealing the same orientation and structure as chromosome 8p23 low-copy repeats but with one duplicated segment not completely present, partly due to the complete sequence not being available for that genomic region.

Back to article page