Measuring and using admixture to study the genetics of complex diseases

Table 1 Diseases with possible genetic components based on ethnic differences in disease rates and hence amenable to admixture mapping

Disease	High-risk groups	Low-risk groups	Relative risk ratio	Reference(s)
Obesity	African women	Europeans	2:4	[64, 65]
	Native Americans
	South Asians (central adiposity,)
	Pacific Islanders, Aboriginal Australians
Non-insulin dependent diabetes (NIDDM)	South Asians, West Africans, Peninsular Arabs, Pacific Islanders and Native Americans	Europeans	4:7	[66, 67]
Hypertension	African Americans, West Africans	Europeans	2:3	[68, 69]
Coronary heart disease	South Asians	West African men	2:4	[70, 71]
End-stage renal disease	Native Americans and African populations	Europeans	N/A	[72]
Dementia	Europeans	African Americans, Hispanic Americans	N/A	[73]
Autoimmune diseases:
Systemic lupus	West Africans	Europeans	N/A	[55]
erythematosus	Native Americans	Europeans
Skin cancer	Europeans		N/A	[74]
Lung cancer	Africans	European Americans, Chinese, Japanese		[75, 76]
Prostate cancer	Africans and African Americans			[77]
Multiple sclerosis	Europeans	Chinese, Japanese, African Americans, Turkmens, Uzbeks, Native Siberians, New Zealand Maoris	N/A	[78]
Osteoporosis	European Americans	African Americans	N/A	[79]

ISSN: 1479-7364